Neural activity modulations and motor recovery following brain-exoskeleton interface mediated stroke rehabilitation

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dc.citation.articleNumber102502en_US
dc.citation.journalTitleNeuroImage: Clinicalen_US
dc.citation.volumeNumber28en_US
dc.contributor.authorBhagat, Nikunj A.en_US
dc.contributor.authorYozbatiran, Nurayen_US
dc.contributor.authorSullivan, Jennifer L.en_US
dc.contributor.authorParanjape, Rutaen_US
dc.contributor.authorLosey, Colinen_US
dc.contributor.authorHernandez, Zacharyen_US
dc.contributor.authorKeser, Zaferen_US
dc.contributor.authorGrossman, Roberten_US
dc.contributor.authorFrancisco, Gerard E.en_US
dc.contributor.authorO'Malley, Marcia K.en_US
dc.contributor.authorContreras-Vidal, Jose L.en_US
dc.contributor.orgMechatronics and Haptic Interfaces Laboratoryen_US
dc.date.accessioned2021-02-08T18:37:45Zen_US
dc.date.available2021-02-08T18:37:45Zen_US
dc.date.issued2020en_US
dc.description.abstractBrain-machine interfaces (BMI) based on scalp EEG have the potential to promote cortical plasticity following stroke, which has been shown to improve motor recovery outcomes. However, the efficacy of BMI enabled robotic training for upper-limb recovery is seldom quantified using clinical, EEG-based, and kinematics-based metrics. Further, a movement related neural correlate that can predict the extent of motor recovery still remains elusive, which impedes the clinical translation of BMI-based stroke rehabilitation. To address above knowledge gaps, 10 chronic stroke individuals with stable baseline clinical scores were recruited to participate in 12 therapy sessions involving a BMI enabled powered exoskeleton for elbow training. On average, 132 ± 22 repetitions were performed per participant, per session. BMI accuracy across all sessions and subjects was 79 ± 18% with a false positives rate of 23 ± 20%. Post-training clinical assessments found that FMA for upper extremity and ARAT scores significantly improved over baseline by 3.92 ± 3.73 and 5.35 ± 4.62 points, respectively. Also, 80% participants (7 with moderate-mild impairment, 1 with severe impairment) achieved minimal clinically important difference (MCID: FMA-UE >5.2 or ARAT >5.7) during the course of the study. Kinematic measures indicate that, on average, participants’ movements became faster and smoother. Moreover, modulations in movement related cortical potentials, an EEG-based neural correlate measured contralateral to the impaired arm, were significantly correlated with ARAT scores (ρ = 0.72, p < 0.05) and marginally correlated with FMA-UE (ρ = 0.63, p = 0.051). This suggests higher activation of ipsi-lesional hemisphere post-intervention or inhibition of competing contra-lesional hemisphere, which may be evidence of neuroplasticity and cortical reorganization following BMI mediated rehabilitation therapy.en_US
dc.identifier.citationBhagat, Nikunj A., Yozbatiran, Nuray, Sullivan, Jennifer L., et al.. "Neural activity modulations and motor recovery following brain-exoskeleton interface mediated stroke rehabilitation." <i>NeuroImage: Clinical,</i> 28, (2020) Elsevier: https://doi.org/10.1016/j.nicl.2020.102502.en_US
dc.identifier.digitalNeural-activity-modulationsen_US
dc.identifier.doihttps://doi.org/10.1016/j.nicl.2020.102502en_US
dc.identifier.urihttps://hdl.handle.net/1911/109806en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordBrain-machine interfaceen_US
dc.subject.keywordStroke rehabilitationen_US
dc.subject.keywordExoskeletonsen_US
dc.subject.keywordClinical trialen_US
dc.subject.keywordMovement related cortical potentialsen_US
dc.titleNeural activity modulations and motor recovery following brain-exoskeleton interface mediated stroke rehabilitationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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