Copper-Catalyzed Synthesis of Hindered Ethers from α-Bromo Carbonyl Compounds
Date
2018
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American Chemical Society
Abstract
A catalytic method for the synthesis of sterically hindered ethers and thioethers from α-bromo carbonyl compounds and the corresponding nucleophiles using an inexpensive Cu(I) catalytic system is reported. This facile transformation takes place at ambient temperature and does not require the exclusion of air or moisture; thus, it is well-suited for the functionalization and derivatization of complex organic molecules.
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Zhou, Zhe, Behnke, Nicole Erin and Kürti, László. "Copper-Catalyzed Synthesis of Hindered Ethers from α-Bromo Carbonyl Compounds." Organic Letters, 20, no. 17 (2018) American Chemical Society: 5452-5456. https://doi.org/10.1021/acs.orglett.8b02371.
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This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.