Synthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue Engineering

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dc.citation.firstpage1788en_US
dc.citation.issueNumber5en_US
dc.citation.journalTitleBiomacromoleculesen_US
dc.citation.lastpage1796en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorWatson, Brendan M.en_US
dc.contributor.authorKasper, F. Kurtisen_US
dc.contributor.authorEngel, Paul S.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.date.accessioned2015-07-10T18:42:19Zen_US
dc.date.available2015-07-10T18:42:19Zen_US
dc.date.issued2014en_US
dc.description.abstractNovel, injectable, biodegradable macromer solutions that form hydrogels when elevated to physiologic temperature via a dual chemical and thermo-gelation were fabricated and characterized. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant phosphate groups was synthesized and subsequently functionalized with chemically cross-linkable methacrylate groups via degradable phosphate ester bonds, yielding a dual-gelling macromer. These dual-gelling macromers were tuned to have transition temperatures between room temperature and physiologic temperature, allowing them to undergo instantaneous thermogelation as well as chemical gelation when elevated to physiologic temperature. Additionally, the chemical cross-linking of the hydrogels was shown to mitigate hydrogel syneresis, which commonly occurs when thermogelling materials are raised above their transition temperature. Finally, degradation of the phosphate ester bonds of the cross-linked hydrogels yielded macromers that were soluble at physiologic temperature. Further characterization of the hydrogels demonstrated minimal cytotoxicity of hydrogel leachables as well as in vitro calcification, making these novel, injectable macromers promising materials for use in bone tissue engineering.en_US
dc.identifier.citationWatson, Brendan M., Kasper, F. Kurtis, Engel, Paul S., et al.. "Synthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue Engineering." <i>Biomacromolecules,</i> 15, no. 5 (2014) American Chemical Society: 1788-1796. http://dx.doi.org/10.1021/bm500175e.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/bm500175een_US
dc.identifier.urihttps://hdl.handle.net/1911/80892en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleSynthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue Engineeringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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