Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues

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dc.citation.firstpage23en_US
dc.citation.journalTitleEnvironment Internationalen_US
dc.citation.lastpage29en_US
dc.citation.volumeNumber88en_US
dc.contributor.authorLeonetti, Christopheren_US
dc.contributor.authorButt, Craig M.en_US
dc.contributor.authorHoffman, Kateen_US
dc.contributor.authorMiranda, Marie Lynnen_US
dc.contributor.authorStapleton, Heather M.en_US
dc.date.accessioned2017-05-03T19:58:19Zen_US
dc.date.available2017-05-03T19:58:19Zen_US
dc.date.issued2016en_US
dc.description.abstractLegacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a suite of PBDEs and 2,4,6-TBP in 102 human placental tissues collected between 2010 and 2011 in Durham County, North Carolina, USA. The most abundant PBDE congener detected was BDE-47, with a mean concentration of 5.09 ng/g lipid (range: 0.12–141 ng/g lipid; detection frequency 91%); however, 2,4,6-TBP was ubiquitously detected and present at higher concentrations with a mean concentration of 15.4 ng/g lipid (range:1.31–316 ng/g lipid; detection frequency 100%). BDE-209 was also detected in more than 50% of the samples, and was significantly associated with 2,4,6-TBP in placental tissues, suggesting they may have a similar source, or that 2,4,6-TBP may be a degradation product of BDE-209. Interestingly, BDE-209 and 2,4,6-TBP were negatively associated with age (rs = − 0.16; p = 0.10 and rs = − 0.17; p = 0.08, respectively). The results of this work indicate that PBDEs and 2,4,6-TBP bioaccumulate in human placenta tissue and likely contribute to prenatal exposures to these environmental contaminants. Future studies are needed to determine if these joint exposures are associated with any adverse health measures in infants and children.en_US
dc.identifier.citationLeonetti, Christopher, Butt, Craig M., Hoffman, Kate, et al.. "Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues." <i>Environment International,</i> 88, (2016) Elsevier: 23-29. https://doi.org/10.1016/j.envint.2015.12.002.en_US
dc.identifier.doihttps://doi.org/10.1016/j.envint.2015.12.002en_US
dc.identifier.urihttps://hdl.handle.net/1911/94148en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordBrominated flame retardantsen_US
dc.subject.keywordPolybrominated diphenyl ethersen_US
dc.subject.keywordThyroid hormoneen_US
dc.subject.keywordPlacentaen_US
dc.titleConcentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissuesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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