Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim

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dc.citation.firstpage1335
dc.citation.issueNumber3
dc.citation.journalTitleMarine Drugs
dc.citation.lastpage1348
dc.citation.volumeNumber12
dc.contributor.authorCheng, Chunwei
dc.contributor.authorLiu, Yan
dc.contributor.authorBalasis, Maria E.
dc.contributor.authorSimmons, Nicholas L.
dc.contributor.authorLi, Jerry
dc.contributor.authorSong, Hao
dc.contributor.authorPan, Lili
dc.contributor.authorQin, Yong
dc.contributor.authorNicolaou, K.C.
dc.contributor.authorSebti, Said M.
dc.contributor.authorLi, Rongshi
dc.date.accessioned2017-08-04T12:30:00Z
dc.date.available2017-08-04T12:30:00Z
dc.date.issued2014
dc.description.abstractA series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is two-fold more potent than 1. Two novel cyclic marinopyrroles (3 and 4) are two- to seven-fold more potent than 1.
dc.identifier.citationCheng, Chunwei, Liu, Yan, Balasis, Maria E., et al.. "Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim." <i>Marine Drugs,</i> 12, no. 3 (2014) MDPI: 1335-1348. https://doi.org/10.3390/md12031335.
dc.identifier.digitalCyclic_Marinopyrrole_Derivatives
dc.identifier.doihttps://doi.org/10.3390/md12031335
dc.identifier.urihttps://hdl.handle.net/1911/96582
dc.language.isoeng
dc.publisherMDPI
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject.keywordcyclic marinopyrroles
dc.subject.keywordprotein-protein interaction disruptors
dc.subject.keywordapoptosis
dc.subject.keywordSAR
dc.titleCyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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