Amino Acid Repeats Cause Extraordinary Coding Sequence Variation in the Social Amoeba Dictyostelium discoideum

dc.citation.firstpagee46150en_US
dc.citation.issueNumber9en_US
dc.citation.journalTitlePLoS Oneen_US
dc.citation.volumeNumber7en_US
dc.contributor.authorScala, Cleaen_US
dc.contributor.authorTian, Xiangjunen_US
dc.contributor.authorMehdiabadi, Natasha J.en_US
dc.contributor.authorSmith, Margaret H.en_US
dc.contributor.authorSaxer, Gerdaen_US
dc.contributor.authorStephens, Katieen_US
dc.contributor.authorBuzombo, Princeen_US
dc.contributor.authorStrassmann, Joan E.en_US
dc.contributor.authorQueller, David C.en_US
dc.date.accessioned2013-01-30T16:31:19Zen_US
dc.date.available2013-01-30T16:31:19Zen_US
dc.date.issued2012-09en_US
dc.description.abstractProtein sequences are normally the most conserved elements of genomes owing to purifying selection to maintain their functions. We document an extraordinary amount of within-species protein sequence variation in the model eukaryote Dictyostelium discoideum stemming from triplet DNA repeats coding for long strings of single amino acids. D. discoideum has a very large number of such strings, many of which are polyglutamine repeats, the same sequence that causes various human neurological disorders in humans, like Huntington's disease. We show here that D. discoideum coding repeat loci are highly variable among individuals, making D. discoideum a candidate for the most variable proteome. The coding repeat loci are not significantly less variable than similar non-coding triplet repeats. This pattern is consistent with these amino-acid repeats being largely non-functional sequences evolving primarily by mutation and drift.en_US
dc.identifier.citationScala, Clea, Tian, Xiangjun, Mehdiabadi, Natasha J., et al.. "Amino Acid Repeats Cause Extraordinary Coding Sequence Variation in the Social Amoeba Dictyostelium discoideum." <i>PLoS One,</i> 7, no. 9 (2012) Public Library of Science: e46150. http://dx.doi.org/10.1371/journal.pone.0046150.en_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0046150en_US
dc.identifier.urihttps://hdl.handle.net/1911/69882en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleAmino Acid Repeats Cause Extraordinary Coding Sequence Variation in the Social Amoeba Dictyostelium discoideumen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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