Faculty & Staff Research
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This community includes faculty journal articles deposited per Rice's Open Access Policy (more information about the policy can be found in this library guide) and additional faculty work. Items found in this community can also be found in the authors' departmental faculty publication collections.
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Item Glossary of some divination related terms(Rice University, 1/13/2012) Smith, Richard J. (Richard Joseph), 1944-Item Glossary of some Yijing-related terms(Rice University, 1/13/2012) Smith, Richard J. (Richard Joseph), 1944-Item Morphological diversity of extracellular vesicles revealed by cryo-electron microscopy(ASEMV/AAEV, 10/1/2022) Kapoor, Kshipra S.; McAndrews, Kathleen M.; Biswal, Lisa S.; Kalluri, RaghuIntroduction: Exosomes are extracellular vesicles 80-150 nm in diameter, containing proteins, mRNAs, microRNAs, and lipids reflecting the parent cell. While there has been an extensive characterization of the cargo incorporated in exosomes, a detailed morphological analysis of exosomes purified by various isolation techniques has not been performed. Objective: We aimed to determine the heterogeneity of exosomes morphology and if such morphological features are conserved across sample types. Methods: Our study used Cryogenic Electron Microscopy (Cryo-EM) to examine exosome size and morphology. Results: Our results revealed significant diversity in extracellular vesicle morphology independent of the isolation method, suggesting that morphological subpopulations of these vesicles exist. Based on their shape, our analysis classified exosomes into seven categories. In addition, we developed a semi-automatic image analysis framework to accurately characterize exosome attributes and distribution to facilitate reliable quantification of specific bio-nanoparticle features in Cryo-EM micrographs. Conclusions: Morphological features of exosomes inform their biophysical properties, which influence both biodistribution and biological activity in vivo. Our data demonstrating the innate morphological diversity of exosomes may have implications for improving the specificity and precision of exosome-delivered therapeutics. Conflict of interest: R.K. and MD Anderson Cancer Center hold patents in exosome biology and are stock equity holders in Codiak Biosciences Inc. R.K. is a consultant and a scientific advisor of Codiak Biosciences Inc.Item Life's Path: The Good, the Bad, and the Just Plain There(11/16/2012) Klein, Anne CarolynItem Increasing influence of medieval architecture upon the architecture of America(1928) Hooton, Claude EdgarItem Street Map, City of Houston, Texas, circa 1930(1930) Texas Map & Blueprint Co.Item Ornament in relation to modern architecture(1934) Talley, Robert WilliamItem The architectural development of the automobile filling station in America(1937) Barrick, Nolan ElmoreItem The unsolved problem of Byzantine architecture; its exterior design(1938) Dunaway, James KarlItem The architecture of the Itza Maya: a study based upon the reports of archaeological findings(1939) Crate, Harry WilliamItem The architectural development of the motion picture theatre(1940) Alexander, Woodrow WilsonItem A memorial to the colonial South(1941) Bland, John DietrichItem A study of super markets(1947) Maurice, Robert WeldonItem Electrodeposition of Aluminum(1948-08-03) Frank H. Hurley; Rice University; William Marsh Rice Institute for the Advancement of Literature, Science and Art, a Corporation of Texas; United States Patent and Trademark OfficeThis invention relates to the electrodeposition of aluminum., and particularly to a process involving the deposition of aluminum on a suitable cathode from an electrolyte comprising a fused or liquid mixture of a suitable aluminum salt with an N-alkyl pyridinium halide.Item Electrodeposition of Aluminum(1948-08-03) Thomas P. Wier, Jr.; Frank H. Hurley; Rice University; William Marsh Rice Institute for the Advancement of Literature, Science and Art, a Corporation of Texas; United States Patent and Trademark OfficeThis invention relates to the electrodeposition of aluminum from a liquid mixture of a nitrogen-substituted alkyl pyridinium chloride or bromide and aluminum chloride.Item Electrodeposition of Aluminum(1948-08-03) Thomas P. Wier, Jr.; Rice University; William Marsh Rice Institute for the Advancement of Literature, Science and Art, a Corporation of Texas; United States Patent and Trademark OfficeThis invention relates to a process for the electrodeposition of aluminum on dissimilar metals.Item A community theatre(1949) Stousland, Charles EugeneItem Shopping centers(1950) Sites, Donald HItem Museums: a study of past thought and modern trends(1950) Brenneman, John HenryItem Enlightened architecture; a study of light-weight materials(1951) Fine, Raymond Kasef; Morehead, James C., Jr.