Browsing by Author "Scott, Graham B. I."

Now showing 1 - 4 of 4
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    Method for creating a functional interface between a nanoparticle- nanotube or nanowire- and a biological molecule or system
    (2010-04-06) Barron, Andrew R.; Flood, Dennis J.; Whitsitt, Elizabeth Anne; Anderson, Robin E.; Scott, Graham B. I.; Rice University; New Cyte, Inc.; United States Patent and Trademark Office
    A field effect transistor and a method for making the same. In one embodiment, the field effect transistor comprises a source; a drain; a gate; at least one carbon nanotube on the gate; and a dielectric layer that coats the gate and a portion of the at least one carbon nanotube, wherein the at least one carbon nanotube has an exposed portion that is not coated with the dielectric layer, and wherein the exposed portion is functionalized with at least one indicator molecule. In other embodiments, the field effect transistor is a biochem-FET.
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    Pulsed-multiline excitation for color-blind fluorescence detection
    (2006-02-07) Scott, Graham B. I.; Kittrell, Carter W.; Curl, Robert F.; Metzker, Michael L.; Rice University; Baylor College of Medicine; United States Patent and Trademark Office
    The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
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    Pulsed-multiline excitation for color-blind fluorescence detection
    (2009-03-31) Scott, Graham B. I.; Kittrell, Carter W.; Curl, Robert F.; Metzker, Michael L.; Baylor College of Medicine; Rice University; United States Patent and Trademark Office
    The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dispersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
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    Pulsed-multiline excitation for color-blind fluorescence detection
    (2012-01-03) Scott, Graham B. I.; Kittrell, Carter W.; Curl, Robert F.; Metzker, Michael L.; Baylor College of Medicine; Rice University; United States Patent and Trademark Office
    The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.