Browsing by Author "Nunes, Joseph John"
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Item A total synthesis of (+,-)-quinocarcin(1988) Nunes, Joseph John; Fukuyama, TohruA synthetic route via the key intermediate DX-52-1 21 has resulted in the first total synthesis of the complex antitumor antibiotic quinocarcin 1. Salient features include an acyliminium ion-mediated stereoselective construction of a diazabicyclo (3.2.1) octane nucleus, a stereoselective Pictet-Spengler cyclization, and a silver assisted conversion of DX-52-1 to the title compound.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)