Browsing by Author "Lamani, Manjunath"

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    Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof
    (2023-02-21) Nicolaou, Kyriacos C.; Rhoades, Derek; Kumar, Soundarapandian M.; Pattanayak, Manas R.; Lamani, Manjunath; Rice University; William Marsh Rice University; United States Patent and Trademark Office
    In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
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    Total Synthesis of Myceliothermophins C, D and E
    (Wiley, 2014) Nicolaou, K.C.; Shi, Lei; Lu, Min; Pattanayak, Manas R.; Shah, Akshay A.; Ioannidou, Heraklidia A.; Lamani, Manjunath; BioScience Research Collaborative
    The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms.