Browsing by Author "Chang, Guoping"

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    A new implementation of Super Resolution technique in PET imaging
    (2008) Chang, Guoping; Clark, John W., Jr.
    A new implementation for Super-Resolution (SR) techniques has been proposed. This new SR implementation has multiple clinical advantages versus the original standard implementation. We tested and validated this new approach by comparing it to the original SR implementation in theoretical and experimental studies. Characterization and evaluation of this new SR processing are also conducted in experimental as well as patient studies. The results show that this new SR implementation can be used to replace the original standard SR implementation while exhibiting similar performance in image resolution and signal-to-noise ratio (SNR).
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    Respiratory motion correction techniques in positron emission tomography/computed tomography (PET/CT) imaging
    (2010) Chang, Guoping; Clark, John W., Jr.
    The aim of this thesis is to design, implement, and evaluate respiratory motion correction techniques that can overcome respiratory motion artifacts in PET/CT imaging. The thesis is composed of three main sections. The first section introduces a novel approach (free-breathing amplitude gating (FBAG) technique) to correct for respiratory motion artifacts. This approach is based on sorting the acquired PET data in multiple amplitude bins which is currently not possible on any commercial PET/CT scanner. The second section is focused on the hardware/software design of an in-house respiratory gating device that is necessary to facilitate the implementation of the FBAG technique. Currently there are no commercially available respiratory gating systems that can generate the necessary triggers required for the FBAG technique. The third section is focused on developing a joint correction technique that can simultaneously suppress respiratory motion artifacts as well as partial volume effects (PVE) which represent another source of image degradation in PET/CT imaging. Computer simulations, phantom studies, as well as patient studies are conducted to test the performance of these proposed techniques and their results are shown in this thesis.