Materials Science and NanoEngineering

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https://hdl.handle.net/1911/76491
In Fall 2013, the Materials Science faculty separated from the MEMS Department and formed the new department of Materials Science and NanoEngineering.

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Browsing Materials Science and NanoEngineering by Author "Acharya, Ghanashyam"

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    Combination Nanomedicine Strategy for Preventing High-Risk Corneal Transplantation Rejection
    (American Chemical Society, 2024) Meng, Tuo; Zheng, Jinhua; Shin, Crystal S.; Gao, Nan; Bande, Divya; Sudarjat, Hadi; Chow, Woon; Halquist, Matthew Sean; Yu, Fu-Shin; Acharya, Ghanashyam; Xu, Qingguo
    High-risk (HR) corneal transplantation presents a formidable challenge, with over 50% of grafts experiencing rejection despite intensive postoperative care involving frequent topical eyedrop administration up to every 2 h, gradually tapering over 6–12 months, and ongoing maintenance dosing. While clinical evidence underscores the potential benefits of inhibiting postoperative angiogenesis, effective antiangiogenesis therapy remains elusive in this context. Here, we engineered controlled-release nanomedicine formulations comprising immunosuppressants (nanoparticles) and antiangiogenesis drugs (nanowafer) and demonstrated that these formulations can prevent HR corneal transplantation rejection for at least 6 months in a clinically relevant rat model. Unlike untreated corneal grafts, which universally faced rejection within 2 weeks postsurgery, a single subconjunctival injection of the long-acting immunosuppressant nanoparticle alone effectively averted graft rejection for 6 months, achieving a graft survival rate of ∼70%. Notably, the combination of an immunosuppressant nanoparticle and an anti-VEGF nanowafer yielded significantly better efficacy with a graft survival rate of >85%. The significantly enhanced efficacy demonstrated that a combination nanomedicine strategy incorporating immunosuppressants and antiangiogenesis drugs can greatly enhance the ocular drug delivery and benefit the outcome of HR corneal transplantation with increased survival rate, ensuring patient compliance and mitigating dosing frequency and toxicity concerns.
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    Metal-Free Dual Modal Contrast Agents Based on Fluorographene Quantum Dots
    (Wiley, 2016) Radhakrishnan, Sruthi; Samanta, Atanu; Sudeep, Parambath M.; Maldonado, Kiersten L.; Mani, Sendurai A.; Acharya, Ghanashyam; Tiwary, Chandra Sekhar; Singh, Abhishek K.; Ajayan, Pulickel M.
    Fluorographene quantum dots prepared from fluorinated graphene oxide (FGO) show a linear dependence of the magnetization on the applied field. This is further supported by DFT calculations taking into account a few possible systems of functionalized graphene quantum dots. The inherent magnetism, high concentration of fluorine and cyto-compatibility of these quantum dots promise potential application as a dual modal agent for proton and 19F based Magnetic Resonance Imaging which is investigated here. A metal free dual modal contrast agent would bring about a great change in the efficiency and resolution of this widely used imaging tool.