This entreaty focuses on the necessary elements to broaden and diversify engagement beyond the Spirit of Asilomar conference community through the creation of a Global Network for Organisms and Multi-disciplinary Exchange (GNOME). The network would build a broader coalition of expertise, experience, perspectives and cultural knowledge to decide on how to use biotechnology to address the biodiversity crisis, and foster collaborative decision-making on the ethical, legal, cultural, and social implications of emerging biotechnologies, especially engaging South-South and South-North stakeholders in connections. GNOME has three key goals - the first is to build and strengthen trust — the most important takeaway from the Spirit of Asilomar meeting — between communities, biotechnologists, conservationists, ecologists, ethicists, and other stakeholders, particularly with the Global South. The second goal is to foster the exchange of technical, cultural values, and local knowledge and perspectives to inform/evolve existing decision-making and operational frameworks for the use of biotech in conservation and the environment. Our final goal is to build responsible and accountable biotech innovation reaffirming local community values, priority needs, the right to withhold consent, self-determination, and the rights of nature. We invite you to join our efforts to design the network, its structure, governance and activities.