Evaluating the Effects of Cell Sample Preparation on FTIR Cancer Detection

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dc.contributor.advisorDrezek, Rebekah A.en_US
dc.contributor.committeeMemberKelly, Kevin F.en_US
dc.contributor.committeeMemberKono, Junichiroen_US
dc.creatorNoelck, Sterlingen_US
dc.date.accessioned2013-09-16T16:04:30Zen_US
dc.date.accessioned2013-09-16T16:04:33Zen_US
dc.date.available2013-09-16T16:04:30Zen_US
dc.date.available2013-09-16T16:04:33Zen_US
dc.date.created2013-05en_US
dc.date.issued2013-09-16en_US
dc.date.submittedMay 2013en_US
dc.date.updated2013-09-16T16:04:33Zen_US
dc.description.abstractThis thesis examines some of the challenges involved with using FTIR spectroscopy for cancer detection including sample preparation and correcting for distortion from cell scattering. Sample preparation affects the spectra differently depending on the cell type, and can lead to significant changes in cancer biomarkers for a given cell type. Biomarkers derived from specific cancer types under one sample preparation are not reliable for other cancer types, and may not be suitable for the same cancer type using a different sample preparation. Cell scattering can also significantly affect the cell spectra, and as a result, correcting for the cell scattering distortion leads to changes in the biomarkers. For reliable cancer detection controlling variability is critical, especially in the complex spectra of biological samples. Standard sample preparation methods and scattering correction post-processing could improve comparison of cancer detection methods.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationNoelck, Sterling. "Evaluating the Effects of Cell Sample Preparation on FTIR Cancer Detection." (2013) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/72015">https://hdl.handle.net/1911/72015</a>.en_US
dc.identifier.slug123456789/ETD-2013-05-514en_US
dc.identifier.urihttps://hdl.handle.net/1911/72015en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectFTIRen_US
dc.subjectSample preparationen_US
dc.subjectCancer cellsen_US
dc.subjectCancer detectionen_US
dc.subjectBiophotonicsen_US
dc.titleEvaluating the Effects of Cell Sample Preparation on FTIR Cancer Detectionen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBiologyen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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