Synthetic studies towards the total synthesis of the saframycins

Simple item page
dc.contributor.advisorFukuyama, Tohru
dc.creatorAjeck-Carman, Karen Lynn
dc.date.accessioned2009-06-04T00:21:36Z
dc.date.available2009-06-04T00:21:36Z
dc.date.issued1988
dc.description.abstractA key improvement to the original saframycin B synthesis involves efficient sequential piperazinedione condensations to yield a basic saframycin skeleton from which all congeners might be made. Approaches toward the total synthesis of saframycin A result in formation of two advanced intermediates. The first, a pentacyclic diphenol nitrile with at least four out of five stereocenters established, is synthesized via a multistep scheme which involves a Pictet-Spengler type phenolic cyclization. The second advanced intermediate is produced via a route which involves cleavage of an imidazolidine ring with concomitant introduction of cyanide. An isomer of saframycin A is synthesized using this approach.
dc.format.extent227 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoThesis Chem. 1988 Ajeck
dc.identifier.citationAjeck-Carman, Karen Lynn. "Synthetic studies towards the total synthesis of the saframycins." (1988) Diss., Rice University. <a href="https://hdl.handle.net/1911/16123">https://hdl.handle.net/1911/16123</a>.
dc.identifier.urihttps://hdl.handle.net/1911/16123
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectOrganic chemistry
dc.titleSynthetic studies towards the total synthesis of the saframycins
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemistry
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
8900216.PDF
Size:
4.82 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Electronic Theses and Dissertations