Building a 3D atlas of the mouse brain

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dc.contributor.advisorWarren, Joeen_US
dc.creatorJu, Taoen_US
dc.date.accessioned2009-06-04T08:20:20Zen_US
dc.date.available2009-06-04T08:20:20Zen_US
dc.date.issued2005en_US
dc.description.abstractBuilding and studying 3D representations of anatomical structures, such as the brain, plays an important role in modern biology and medical science. While 3D imaging methods such as MRI and CT have been widely applied, 2D imaging methods such as optical microscopy typically generate images with much higher resolution. In this thesis I describe how to construct a high-resolution 3D atlas of the mouse brain from 2D microscopic images. In particular, I focus on using computer graphics techniques, such as image registration to correcting tissue distortions and polygonal modeling to build surfaces representing the partitioning of anatomical regions. The methods are being applied to construct a high-quality polygonal atlas of an adult mouse brain from 350 histological tissue sections. While the resulting brain atlas will contribute to a larger project of building a spatial database of gene expressions over the mouse brain, the methods described in this thesis are well suited for the general purpose of building polygonal atlases of arbitrary anatomical structures from tissue sections.en_US
dc.format.extent99 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS COMP.SCI. 2005 JUen_US
dc.identifier.citationJu, Tao. "Building a 3D atlas of the mouse brain." (2005) Diss., Rice University. <a href="https://hdl.handle.net/1911/18769">https://hdl.handle.net/1911/18769</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/18769en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectNeurosciencesen_US
dc.subjectComputer scienceen_US
dc.subjectBiologyen_US
dc.titleBuilding a 3D atlas of the mouse brainen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentComputer Scienceen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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