Theoretical Investigations of Mechanisms of Bacterial Clearance by Antimicrobial Peptides

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dc.contributor.advisorKolomeisky, Anatoly Ben_US
dc.creatorNguyen, Thao Nen_US
dc.date.accessioned2022-09-23T18:21:59Zen_US
dc.date.available2022-09-23T18:21:59Zen_US
dc.date.created2022-08en_US
dc.date.issued2022-09-07en_US
dc.date.submittedAugust 2022en_US
dc.date.updated2022-09-23T18:21:59Zen_US
dc.description.abstractThe discovery and subsequent clinical usage of antibiotics was a major breakthrough in 20th-century medicine, drastically improving healthcare standards while increasing the average human life expectancy. The antibiotic era, despite its considerable success, was unfortunately short-lived. Once again, the threat of potential lack of treatments for infectious diseases returns, this time due to the emergence of multidrug-resistant bacteria. Limitations in the number of bacterial targets remain among the main challenges in discovering new antibiotics. In order to overcome this shortage, a promising solution is using antimicrobial peptides (AMPs), a strong naturally occurring alternative. We developed a theoretical framework for the interactions of AMPs and bacteria on both the single-cell and population level, with and without considering the synergistic combination of different types of AMPs. Our methods explain the wide spectrum of efficiencies at which different types of AMPs operate while indicating the equivalent significance of the bacterial cell entrance and inhibition processes. Measures of minimal inhibitory concentration (MIC) as well as our cooperativity parameter in the 2-AMP cases were detailed, offering a physical-chemical description of the mechanisms of cooperativity and the overall bacterial clearance dynamics.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationNguyen, Thao N. "Theoretical Investigations of Mechanisms of Bacterial Clearance by Antimicrobial Peptides." (2022) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/113276">https://hdl.handle.net/1911/113276</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/113276en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectantimicrobial peptidesen_US
dc.subjectmaster equationsen_US
dc.subjectminimal inhibitory concentrationen_US
dc.subjectfractional inhibitory concentrationen_US
dc.titleTheoretical Investigations of Mechanisms of Bacterial Clearance by Antimicrobial Peptidesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentApplied Physicsen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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