Nitric Oxide: The Missing Link in Omentum-Induced Metabolic reprogramming of ovarian cancers

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dc.contributor.advisorNagrath, Deepak
dc.contributor.committeeMemberZygourakis, Kyriacos
dc.contributor.committeeMemberBennett, George
dc.contributor.committeeMemberKlopp, Ann H
dc.creatorSalimian Rizi, Bahar
dc.date.accessioned2016-01-26T21:04:52Z
dc.date.available2016-01-26T21:04:52Z
dc.date.created2015-12
dc.date.issued2015-11-24
dc.date.submittedDecember 2015
dc.date.updated2016-01-26T21:04:52Z
dc.description.abstractA novel metabolic regulatory mechanism of ovarian cancer by omentum adipose-derived stroma cells (O-ASCs) has been discovered. O-ASCs induce survival, migration, and chemoresistance of ovarian cancer cells. However, the underpinning mechanism behind the metabolic modulation was not understood. Here, O-ASCs are shown to promote nitric oxide (NO) homeostasis in ovarian cancers by generating the pool of arginine. Ovarian cancer cells benefit from tumor microenvironment’s elements and expand their growth. In turn, cancer cells modify the elements’ fate to further take advantage of nutrients and resources. A unique combinatory drug treatment is proposed to target O-ASCs-induced chemoresistance of ovarian cancer cells.
dc.format.mimetypeapplication/pdf
dc.identifier.citationSalimian Rizi, Bahar. "Nitric Oxide: The Missing Link in Omentum-Induced Metabolic reprogramming of ovarian cancers." (2015) Diss., Rice University. <a href="https://hdl.handle.net/1911/88140">https://hdl.handle.net/1911/88140</a>.
dc.identifier.urihttps://hdl.handle.net/1911/88140
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectOvarian cancer metabolism
dc.subjecttumor microenvironment
dc.subjectcancer metabolism
dc.subjectnitric oxide
dc.subjectarginine metabolism
dc.subjectomentum
dc.titleNitric Oxide: The Missing Link in Omentum-Induced Metabolic reprogramming of ovarian cancers
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemical and Biomolecular Engineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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