The development of gold nanoparticle conjugates for the intracellular delivery of paclitaxel
| dc.contributor.advisor | Zubarev, Eugene | |
| dc.creator | Gibson, Jacob | |
| dc.date.accessioned | 2011-07-25T02:05:46Z | |
| dc.date.available | 2011-07-25T02:05:46Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | The following work describes our efforts toward the development of a novel gold nanoparticle (AuNP) system capable of the quantitative intracellular delivery of the known chemotherapeutic, paclitaxel. The synthetic strategy employed here features the covalent grafting of multiple drug molecules to the surface of individual gold nanocrystals measuring 2 nm in diameter. This core-shell approach is advantageous as it allows for structural analysis based on traditional analytical techniques and, therefore, definitive confirmation of chemical structure. Perhaps more importantly, the ability to manufacture such a well-defined delivery system allows one to more accurately quantify the amount of bound drug and ultimately, biological activity. While varying the linker structure results in analogous paclitaxel-AuNP conjugates capable of drug release based on endogenous biological processes, a study of the inherent intracellular behavior of these gold nanoparticles led to the discovery of a specific functionality required for efficient drug dissociation under cellular conditions. In fact, results from cell culture experiments reveal this novel delivery system as having comparable toxicity to that of the parent drug, while demonstrating a marked reduction in systemic toxicity in animal models. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.callno | THESIS CHEM. 2010 GIBSON | |
| dc.identifier.citation | Gibson, Jacob. "The development of gold nanoparticle conjugates for the intracellular delivery of paclitaxel." (2010) Diss., Rice University. <a href="https://hdl.handle.net/1911/62055">https://hdl.handle.net/1911/62055</a>. | |
| dc.identifier.uri | https://hdl.handle.net/1911/62055 | |
| dc.language.iso | eng | |
| dc.rights | Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder. | |
| dc.subject | Organic chemistry | |
| dc.title | The development of gold nanoparticle conjugates for the intracellular delivery of paclitaxel | |
| dc.type | Thesis | |
| dc.type.material | Text | |
| thesis.degree.department | Chemistry | |
| thesis.degree.discipline | Natural Sciences | |
| thesis.degree.grantor | Rice University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy |
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