Synthesis, Characterization, and Biological uses of Carbon Nanoparticles

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dc.contributor.advisorTour, James M.en_US
dc.contributor.committeeMemberBillups, W. Edwarden_US
dc.contributor.committeeMemberMikos, Antonios G.en_US
dc.creatorMarcano Quevedo, Danielaen_US
dc.date.accessioned2013-07-24T19:37:42Zen_US
dc.date.accessioned2013-07-24T19:37:51Zen_US
dc.date.available2013-07-24T19:37:42Zen_US
dc.date.available2013-07-24T19:37:51Zen_US
dc.date.created2012-12en_US
dc.date.issued2013-07-24en_US
dc.date.submittedDecember 2012en_US
dc.date.updated2013-07-24T19:37:52Zen_US
dc.description.abstractMany diseases have been associated with oxidative stress (OS) which is caused when the production of reactive oxygen species (ROS), such as superoxide (O2•-) and hydroxyl radical (•OH), overcome the scavenging efficiency of living organisms. It is known that ROS production is worsened during traumas related to ischemic events and subsequent reperfusion in which the treatment with fast and effective antioxidants is critical to prevent cell and tissue damage. PEG-HCCs are carbon nanoparticles that showed O2•- and •OH scavenging properties according to electron paramagnetic resonance (EPR) experiments and peroxyl scavenging properties based on oxygen radical absorbance capacity (ORAC) assays. The O2•- quenching capability was also examined in vivo using a mild traumatic brain injury (mTBI) model complicated with hypotension. As result of the PEG-HCCs treatment, the cerebral blood flow (CBF) was restored while normalizing O2•- and nitric oxide (NO•) levels, primarily in the cerebral vasculatureen_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationMarcano Quevedo, Daniela. "Synthesis, Characterization, and Biological uses of Carbon Nanoparticles." (2013) Diss., Rice University. <a href="https://hdl.handle.net/1911/71673">https://hdl.handle.net/1911/71673</a>.en_US
dc.identifier.slug123456789/ETD-2012-12-294en_US
dc.identifier.urihttps://hdl.handle.net/1911/71673en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectPEG-HCCsen_US
dc.subjectNanoparticlesen_US
dc.subjectAntioxidantsen_US
dc.subjectDrug deliveryen_US
dc.subjectGraphene oxideen_US
dc.titleSynthesis, Characterization, and Biological uses of Carbon Nanoparticlesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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