Change in cell motility and metabolism following culture under low shear conditions

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dc.contributor.advisorZygourakis, Kyriacosen_US
dc.creatorLennon, Sean Patricken_US
dc.date.accessioned2018-12-03T18:31:20Zen_US
dc.date.available2018-12-03T18:31:20Zen_US
dc.date.issued2008en_US
dc.description.abstractRecent studies suggest that the human immune system, and in particular lymphocyte function, may be suppressed during space flight. However, the mechanisms by which mechanical forces affect the function of immune cells are still poorly understood. Research performed in our laboratory indicates that culturing lymphocytes under low shear conditions (in rotating wall vessels) leads to an increase in cell motility and altered cell morphology. We have hypothesized that fundamental changes in the cytoskeleton, caused by changes in external forces, could lead to secondary changes in cellular metabolism, which could in turn be reflected by altered membrane structure. Utilizing NMR to investigate changes in lymphocyte function in an altered mechanical environment, we observed significant changes in cell metabolism following cell culture in the RWV, as compared to cells cultured statically. Our research seeks to advance the understanding of how microgravity affects the function of individual cells and how these cells interact with their environment.en_US
dc.format.extent79 ppen_US
dc.identifier.callnoTHESIS CH.E. 2008 LENNONen_US
dc.identifier.citationLennon, Sean Patrick. "Change in cell motility and metabolism following culture under low shear conditions." (2008) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/103549">https://hdl.handle.net/1911/103549</a>.en_US
dc.identifier.digital304508188en_US
dc.identifier.urihttps://hdl.handle.net/1911/103549en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCellular biologyen_US
dc.subjectBiomedical researchen_US
dc.subjectChemical engineeringen_US
dc.subjectApplied sciencesen_US
dc.subjectBiological sciencesen_US
dc.titleChange in cell motility and metabolism following culture under low shear conditionsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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