FGFR4 and β-Klotho in Metastatic Prostate Cancer

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dc.contributor.advisorLwigale, Peter Yunjuen_US
dc.contributor.committeeMemberFarach-Carson, Cindyen_US
dc.contributor.committeeMemberCarson, Daniel D.en_US
dc.contributor.committeeMemberWagner, Daniel S.en_US
dc.contributor.committeeMemberQutub, Amina A.en_US
dc.creatorShenefelt, Dereken_US
dc.date.accessioned2013-07-24T19:47:16Zen_US
dc.date.accessioned2013-07-24T19:47:21Zen_US
dc.date.available2013-07-24T19:47:16Zen_US
dc.date.available2013-07-24T19:47:21Zen_US
dc.date.created2012-12en_US
dc.date.issued2013-07-24en_US
dc.date.submittedDecember 2012en_US
dc.date.updated2013-07-24T19:47:21Zen_US
dc.description.abstractFGFR4 and β-Klotho in Metastatic Prostate Cancer by Derek LaMar Shenefelt Fibroblast growth factors and fibroblast growth factor receptors have been associated with the aggressiveness and progression of Prostate Cancer (PCa). Also, β-Klotho is a known co-receptor with FGFR4 for FGF19 in the liver however, the role of this co-receptor pair remains unclear in the setting of PCa. I demonstrated that FGFR4 and KLB mRNA and protein are highly expressed in PCa cells when compared to bone marrow stromal cells, a common site of metastasis. I also provide support for the association of FGFR4 and KLB in PCa, suggesting a functional co-receptor pair capable of altering cellular signaling. FGFR4-KLb may also provide some level of protection to PCa cells from chemotherapeutics. This analysis of FGFR4 and KLB expression and signaling in PCa has provided novel insights into phenotypic alterations during PCa progression while also providing new avenues of study to further explore the role and importance of this exciting co-receptor complex.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationShenefelt, Derek. "FGFR4 and β-Klotho in Metastatic Prostate Cancer." (2013) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/71689">https://hdl.handle.net/1911/71689</a>.en_US
dc.identifier.slug123456789/ETD-2012-12-259en_US
dc.identifier.urihttps://hdl.handle.net/1911/71689en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectFibroblast growth factor receptor 4en_US
dc.subjectFGFR4en_US
dc.subjectBeta-klothoen_US
dc.subjectKLBen_US
dc.subjectProstate canceren_US
dc.subjectBone metastasisen_US
dc.titleFGFR4 and β-Klotho in Metastatic Prostate Canceren_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBiochemistry and Cell Biologyen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Artsen_US
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