The Impact of D-amino acids on Formation and Integrity of Biofilm – Effect of Growth Condition and Bacteria Type

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dc.contributor.advisorLi, Qilinen_US
dc.contributor.committeeMemberAlvarez, Pedro J.en_US
dc.contributor.committeeMemberTomson, Mason B.en_US
dc.creatorLi, Xueningen_US
dc.date.accessioned2013-09-16T15:52:32Zen_US
dc.date.accessioned2013-09-16T15:52:51Zen_US
dc.date.available2013-09-16T15:52:32Zen_US
dc.date.available2013-09-16T15:52:51Zen_US
dc.date.created2013-05en_US
dc.date.issued2013-09-16en_US
dc.date.submittedMay 2013en_US
dc.date.updated2013-09-16T15:52:51Zen_US
dc.description.abstractBiofouling is a major issue in applying nanofiltration and reverse osmosis technologies for wastewater treatment. Biofilm formed on the surface of membranes will severely decline the flux and cause energy waste. In this study, a novel biofouling control method that applies D-amino acids to inhibit biofilm formation was investigated. The D-amino acids previously reported to inhibit biofilm formation and disrupt existing biofilm – D-tyrosine and the mixture of D-tyrosine, D-tryptophan, D-leucine and D-methionine were tested. Pseudomonas aeruginosa and Bacillus subtilis were used as model Gram-negative and Gram-positive bacteria, respectively. D-amino acids have little effect and some effect on inhibition of biofilm formation and disruption of exiting biofilm to Pseudomonas aeruginosa, but have good effect to Bacillus subtilis. A commonly used microtiter plate assay for quantitative biofilm measurement was systematically evaluated and optimized for screening biofilm control agents. The effect of D-tyrosine on inhibition of organic fouling and P. aeruginosa biofouling on NF90 membrane surface in bench scale dead end filtration experiment was examined, which shows that D-tyrosine can effectively inhibit organic fouling and P. aeruginosa biofouling on NF90 membrane surface.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationLi, Xuening. "The Impact of D-amino acids on Formation and Integrity of Biofilm – Effect of Growth Condition and Bacteria Type." (2013) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/71991">https://hdl.handle.net/1911/71991</a>.en_US
dc.identifier.slug123456789/ETD-2013-05-519en_US
dc.identifier.urihttps://hdl.handle.net/1911/71991en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectAnti-biofoulingen_US
dc.subjectNF/RO membraneen_US
dc.subjectD-amino acidsen_US
dc.subjectMicrotiter plate assayen_US
dc.titleThe Impact of D-amino acids on Formation and Integrity of Biofilm – Effect of Growth Condition and Bacteria Typeen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentCivil and Environmental Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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