Synthetic studies towards the luzopeptins: New amino acid synthons through the aza-Achmatowicz reaction
Date
1992
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Abstract
A new method for the enantioselective synthesis of unusual amino acids has been developed. The chemoenzymatic aza-Achmatowicz rearrangement of appropriate furylglycine derivatives provided nitrogenous synthons that were readily converted to amino acid building blocks. An application of the new chemistry to the synthesis of the unique pyridazine carboxylic acid component of luzopeptins is presented. Luzopeptin C has potent inhibitory activity towards the reverse transcriptase of HIV as the causative agent of AIDS.
Description
Advisor
Degree
Master of Science
Type
Thesis
Keywords
Organic chemistry, Pharmaceutical chemistry
Citation
Shimizu, Toshio. "Synthetic studies towards the luzopeptins: New amino acid synthons through the aza-Achmatowicz reaction." (1992) Master’s Thesis, Rice University. https://hdl.handle.net/1911/13607.
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