Mechanical Interaction between Cells and Extra Cellular Matrix

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dc.contributor.advisorLevine, Herberten_US
dc.creatorFeng, Jingchenen_US
dc.date.accessioned2017-07-31T18:12:41Zen_US
dc.date.available2017-07-31T18:12:41Zen_US
dc.date.created2016-12en_US
dc.date.issued2016-08-29en_US
dc.date.submittedDecember 2016en_US
dc.date.updated2017-07-31T18:12:41Zen_US
dc.description.abstractThe mechanical interactions between Cells and Extracellular Matrix (ECM) play a central role in various cellular processes including motility, differentiation, shape change and wound healing. Contracting cells actively pull the surrounding ECM and cause its remodeling. At the same time, the remodeled ECM in turn regulates both cell mechanical behavior and gene expression. To understand ECM remodeling and its impact on cell regulation, we first construct two continuum theories, a Landau-type theory and a scaling law-type theory, to understand the nonlinear elasticity of ECM. The former elucidates the relation between fiber alignment and nonlinear elasticity, while the later generalizes previous scaling laws and reveals new mechanical regimes in the phase diagram. Next, we build an elastic model, which explicitly includes both cells and collagen fibers, to explore the micromechanics of cellularized ECM on the scale of cell size. It shows that contracting cells remodel the micromechanics of their surrounding ECM in a strain and distance-dependent manner. Finally, we introduce the viscoelastic feature into this model and show viscoelasticity is essential in ECM remodeling. This work provides a platform to study Cell-ECM interactions regulated cell motility and it potentially serves as a guide for experimental work.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationFeng, Jingchen. "Mechanical Interaction between Cells and Extra Cellular Matrix." (2016) Diss., Rice University. <a href="https://hdl.handle.net/1911/95634">https://hdl.handle.net/1911/95634</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/95634en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCell-ECM interactionen_US
dc.subjectmicromechanicsen_US
dc.subjectcontinuum nonlinear elastic theoryen_US
dc.subjectdiscrete modelen_US
dc.subjectviscoelasticityen_US
dc.titleMechanical Interaction between Cells and Extra Cellular Matrixen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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