Mathematical models of atrial and ventricular myocytes from the rabbit heart

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dc.contributor.advisorClark, John W., Jr.en_US
dc.creatorMurphey, Carey Richarden_US
dc.date.accessioned2009-06-03T23:52:30Zen_US
dc.date.available2009-06-03T23:52:30Zen_US
dc.date.issued1991en_US
dc.description.abstractMathematical models of rabbit atrial and ventricular myocytes that are based on quantitative voltage clamp data from emzymatically isolated cardiac myocytes have been developed. These models are capable of accurately simulating the transmembrane ionic currents recorded in response to a step change in membrane potential (whole-cell voltage clamp response), the nonpropagated membrane action potential (MAP), and the frequency-dependent action potential waveshape changes occurring in response to variations in rate of stimulation. Rectangular pulse, ramp and action potential voltage-clamp measurements of the transmembrane ionic currents have allowed us to model a number of processes thought to be important during repolarization. These computations provide important biophysical insights into the electrophysiological activity of atrial and ventricular cells and their associated intra- and extracellular ionic concentration changes. The present model also has useful predictive capabilities. We have used the model to: (1) estimate the intracellular $Ca\sp{2+}$ transient in these myocytes and to compare the relative occupancy of the $Ca\sp{2+}$ binding sites in the contractile proteins with known cellular mechanical activity, and (2) predict the response of the atrial cell to potassium current blockade via $BaCl\sb2$ to the bathing medium.en_US
dc.format.extent101 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoThesis E.E. 1991 Murpheyen_US
dc.identifier.citationMurphey, Carey Richard. "Mathematical models of atrial and ventricular myocytes from the rabbit heart." (1991) Diss., Rice University. <a href="https://hdl.handle.net/1911/16466">https://hdl.handle.net/1911/16466</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/16466en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectPhysiologyen_US
dc.subjectPhysicsen_US
dc.subjectElectromagneticsen_US
dc.subjectBiomedical engineeringen_US
dc.titleMathematical models of atrial and ventricular myocytes from the rabbit hearten_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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