The energy of breathing in a nonlinear model of the human lung

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dc.contributor.advisorGhorbel, Fathi H.
dc.contributor.advisorClark, John W., Jr.
dc.creatorAthanasiades, Athanasios
dc.date.accessioned2009-06-04T06:53:19Z
dc.date.available2009-06-04T06:53:19Z
dc.date.issued1997
dc.description.abstractA Lagrangian approach is used to perform an energy analysis on a nonlinear model of the human lung. Energy functions associated with the mechanics of breathing are obtained. Analytical expressions are derived for the work of breathing (WOB) and are subsequently evaluated for a typical pulmonary function laboratory test that includes tidal breathing, panting and the forced vital capacity maneuvers. The analysis successfully mimics information presented in the conventional Campbell diagram, which is often used to graphically estimate the work of breathing. In addition, it reveals dynamic aspects of muscular effort during a breathing cycle that are not immediately apparent in the Campbell diagram. Additional simulations, based on an expanded model that accounts for gas compressibility, reveal that WOB is underestimated during forceful breathing maneuvers when compressibility effects are ignored. The energy analysis provides valuable insight into the mechanics of respiration, and, in particular, the significance of individual model components.
dc.format.extent62 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS M.E. 1997 ATHANASIADES
dc.identifier.citationAthanasiades, Athanasios. "The energy of breathing in a nonlinear model of the human lung." (1997) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17061">https://hdl.handle.net/1911/17061</a>.
dc.identifier.urihttps://hdl.handle.net/1911/17061
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectApplied mechanics
dc.subjectPhysiology
dc.subjectBiomedical engineering
dc.titleThe energy of breathing in a nonlinear model of the human lung
dc.typeThesis
dc.type.materialText
thesis.degree.departmentMechanical Engineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
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