A 3D microfluidic tumor model to study immune cell infiltration into solid tumors

Simple item page
dc.contributor.advisorDiehl, Michaelen_US
dc.creatorVu, Timothy Qen_US
dc.date.accessioned2019-05-16T20:21:38Zen_US
dc.date.available2019-05-16T20:21:38Zen_US
dc.date.created2017-08en_US
dc.date.issued2017-08-07en_US
dc.date.submittedAugust 2017en_US
dc.date.updated2019-05-16T20:21:38Zen_US
dc.description.abstractThe tumor microenvironment consists of other cells besides cancer cells, including immune cells like T-cells, natural killer cells, and macrophages. The roles of these infiltrated cells, however, are diverse and can be both pro- or anti-tumorigenic. The effects of infiltrated natural killer cells are poorly characterized and highly misunderstood. To better study both the mechanics and effects of infiltrating NK cells, advances to 3D in vitro cancer models are necessary. To this end, I have developed a novel microfluidic device for culturing 3D tumor tissue, which can recapitulate the interstitial flow and gradient microenvironment. I utilize this device to create novel methods in quantifying NK cell infiltration and demonstrate the utility of this device for both infiltration and post-infiltration analysis.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationVu, Timothy Q. "A 3D microfluidic tumor model to study immune cell infiltration into solid tumors." (2017) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/105504">https://hdl.handle.net/1911/105504</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/105504en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectMicrofluidicsen_US
dc.subjectCancer microenvironmenten_US
dc.subject3D cultureen_US
dc.subjectnatural killer cellsen_US
dc.subjectinterstitial flowen_US
dc.titleA 3D microfluidic tumor model to study immune cell infiltration into solid tumorsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.majorBiomedical Engineeringen_US
thesis.degree.nameMaster of Scienceen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
VU-DOCUMENT-2017.pdf
Size:
2.82 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.84 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
2.6 KB
Format:
Plain Text
Description:
Download
Collections
Rice University Theses and Dissertations