A 3D microfluidic tumor model to study immune cell infiltration into solid tumors

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dc.contributor.advisorDiehl, Michael
dc.creatorVu, Timothy Q
dc.date.accessioned2019-05-16T20:21:38Z
dc.date.available2019-05-16T20:21:38Z
dc.date.created2017-08
dc.date.issued2017-08-07
dc.date.submittedAugust 2017
dc.date.updated2019-05-16T20:21:38Z
dc.description.abstractThe tumor microenvironment consists of other cells besides cancer cells, including immune cells like T-cells, natural killer cells, and macrophages. The roles of these infiltrated cells, however, are diverse and can be both pro- or anti-tumorigenic. The effects of infiltrated natural killer cells are poorly characterized and highly misunderstood. To better study both the mechanics and effects of infiltrating NK cells, advances to 3D in vitro cancer models are necessary. To this end, I have developed a novel microfluidic device for culturing 3D tumor tissue, which can recapitulate the interstitial flow and gradient microenvironment. I utilize this device to create novel methods in quantifying NK cell infiltration and demonstrate the utility of this device for both infiltration and post-infiltration analysis.
dc.format.mimetypeapplication/pdf
dc.identifier.citationVu, Timothy Q. "A 3D microfluidic tumor model to study immune cell infiltration into solid tumors." (2017) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/105504">https://hdl.handle.net/1911/105504</a>.
dc.identifier.urihttps://hdl.handle.net/1911/105504
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectMicrofluidics
dc.subjectCancer microenvironment
dc.subject3D culture
dc.subjectnatural killer cells
dc.subjectinterstitial flow
dc.titleA 3D microfluidic tumor model to study immune cell infiltration into solid tumors
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBioengineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.majorBiomedical Engineering
thesis.degree.nameMaster of Science
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