Minimally invasive reliable implantation of ultra-flexible electrodes for non-human primates

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dc.contributor.advisorXie, Chongen_US
dc.creatorYip, Victoren_US
dc.date.accessioned2024-01-22T22:19:38Zen_US
dc.date.available2024-01-22T22:19:38Zen_US
dc.date.created2023-12en_US
dc.date.issued2023-11-28en_US
dc.date.submittedDecember 2023en_US
dc.date.updated2024-01-22T22:19:38Zen_US
dc.descriptionEMBARGO NOTE: This item is embargoed until 2025-12-01en_US
dc.description.abstractUltra-flexible nanoelectric threads (NETs) have been successful in recording neural data in high densities in the cortical and sub-cortical regions, while avoiding post-surgery complications such as foreign-body responses or additional glial scarring from motion when compared to rigid electrodes. Studying sub-cortical brain function is important to understand lower-level brain activity and is mostly exclusive to microelectrodes that can be positioned close to the neurons of interest. To deliver the NET into the brain, a stiff shuttle is used to penetrate the brain tissue. The current T-shaped needle-and-thread shuttle has been successful for transdural implantation in rodents but struggles to scale to larger models. In this thesis, we intend to demonstrate the following: (1) The hook shuttle can be fabricated and successfully and reliably delivers NETs into the brain in rodent models. (2) The hook shuttle performs better than the T-shape shuttle by decreasing the required insertion force. (3) A cannula can be fabricated to help a shuttle deliver NETs into a non-human primate brain by reducing the required insertion force, demonstrated with parafilm and agarose gel phantoms.en_US
dc.embargo.lift2025-12-01en_US
dc.embargo.terms2025-12-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationYip, Victor. "Minimally invasive reliable implantation of ultra-flexible electrodes for non-human primates." (2023) Master's thesis, Rice University. https://hdl.handle.net/1911/115358en_US
dc.identifier.urihttps://hdl.handle.net/1911/115358en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectnon-human primatesen_US
dc.subjectultra-flexible electrodesen_US
dc.subjectmouseen_US
dc.subjectimplantationen_US
dc.subjectbrainen_US
dc.titleMinimally invasive reliable implantation of ultra-flexible electrodes for non-human primatesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical and Computer Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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