An ionic current model for neurons in the rat medial nucleus tractus solitarius receiving sensory afferent input

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dc.contributor.advisorClark, John W., Jr.en_US
dc.creatorKhushalani, Samiren_US
dc.date.accessioned2009-06-04T00:06:57Zen_US
dc.date.available2009-06-04T00:06:57Zen_US
dc.date.issued1992en_US
dc.description.abstractAn ionic current model has been developed for the rat medial nucleus tractus solitarius (mNTS) neuron that provides a quantitative description of the ionic macrocurrents present in the soma of the cell, and their interaction in the genesis of patterned electrical activity. It consists of two parts, a model of the somatic membrane, and a fluid compartment model of the intra- and extracellular media. The somatic membrane model is of Hodgkin-Huxley form, and includes mathematical descriptions of time- and voltage-dependent ion selective channels, as well as pump, exchanger and other background currents present in the generic mNTS neuron. The lumped fluid compartment model accounts for intracellular changes in the $Ca\sp{2+}$ concentration. The model is able to successfully mimic the response of the neuron to different sequences of depolarizing and hyperpolarizing pulses, and has provided useful insights into the biophysical interactions underlying the phenomena of delayed excitation (DE) and spike frequency adaptation (SFA).en_US
dc.format.extent78 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoThesis E.E. 1992 Khushalanien_US
dc.identifier.citationKhushalani, Samir. "An ionic current model for neurons in the rat medial nucleus tractus solitarius receiving sensory afferent input." (1992) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13620">https://hdl.handle.net/1911/13620</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/13620en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiomedical engineeringen_US
dc.subjectBiophysicsen_US
dc.subjectNeurosciencesen_US
dc.subjectBiologyen_US
dc.subjectEngineeringen_US
dc.titleAn ionic current model for neurons in the rat medial nucleus tractus solitarius receiving sensory afferent inputen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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