Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration

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dc.contributor.advisorMikos, Antonios G.en_US
dc.contributor.committeeMemberKasper, Kurten_US
dc.contributor.committeeMemberGrande-Allen, K. Janeen_US
dc.contributor.committeeMemberBennett, George N.en_US
dc.contributor.committeeMemberWong, Mark E.en_US
dc.creatorSpicer, Patricken_US
dc.date.accessioned2013-09-16T16:39:59Zen_US
dc.date.accessioned2013-09-16T16:41:17Zen_US
dc.date.available2013-09-16T16:39:59Zen_US
dc.date.available2013-09-16T16:41:17Zen_US
dc.date.created2013-05en_US
dc.date.issued2013-09-16en_US
dc.date.submittedMay 2013en_US
dc.date.updated2013-09-16T16:41:17Zen_US
dc.description.abstractCraniofacial defects resulting from trauma and resection present many challenges to reconstruction due to the complex structure, combinations of tissues, and environment, with exposure to the oral, skin and nasal mucosal pathogens. Tissue engineering seeks to regenerate the tissues lost in these defects; however, the composite nature and proximity to colonizing bacteria remain difficult to overcome. Additionally, many tissue engineering approaches have further hurdles to overcome in the regulatory process to clinical translation. As such these studies investigated a two stage strategy employing an antibiotic-releasing porous polymethylmethacrylate space maintainer fabricated with materials currently part of products approved or cleared by the United States Food and Drug Administration, expediting the translation to the clinic. This porous space maintainer holds the bone defect open allowing soft tissue to heal around the defect. The space maintainer can then be removed and one regenerated in the defect. These studies investigated the individual components of this strategy. The porous space maintainer showed similar soft tissue healing and response to non-porous space maintainers in a rabbit composite tissue defect. In humans, the porous space maintainers were well tolerated and maintained a soft tissue envelope for closure after implantation of a bone regeneration technology. The antibiotic-releasing space maintainers showed release of antibiotics from 1-5 weeks, which could be controlled by loading and fabrication parameters. In vivo, space maintainers releasing a high dose of antibiotics for an extended period of time increased soft tissue healing over burst release space maintainers in an infected composite tissue defect model in a rabbit mandible. Finally, stabilization of bone defects and regeneration could be improved through scaffold structures and delivery of a bone forming growth factor. These studies illustrate the possibility of the two stage strategy for repair of composite tissue defects of the craniofacial complex.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationSpicer, Patrick. "Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration." (2013) Diss., Rice University. <a href="https://hdl.handle.net/1911/72042">https://hdl.handle.net/1911/72042</a>.en_US
dc.identifier.slug123456789/ETD-2013-05-348en_US
dc.identifier.urihttps://hdl.handle.net/1911/72042en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectTissue engineeringen_US
dc.subjectCraniofacial reconstructionen_US
dc.subjectBiomaterialsen_US
dc.subjectDrug deliveryen_US
dc.subjectComposite tissue defectsen_US
dc.titleTwo Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regenerationen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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