Computational and experimental models of vascular transport in engineered tissues

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dc.contributor.advisorMiller, Jordan S
dc.contributor.committeeMemberDickinson, Mary E
dc.creatorPaulsen, Samantha Jean
dc.date.accessioned2019-05-17T15:01:36Z
dc.date.available2019-05-17T15:01:36Z
dc.date.created2018-05
dc.date.issued2018-04-19
dc.date.submittedMay 2018
dc.date.updated2019-05-17T15:01:37Z
dc.description.abstractAs tissue engineering advances from developing simple two-dimensional (2D) constructs towards the development of thick three-dimensional (3D) tissues on the scale of human organs, the transport of oxygen and nutrients to cells via functional vasculature becomes a paramount engineering challenge. Our field lacks methodologies to fabricate the requisite architecture, while quantitative workflows to predict and evaluate the effectiveness of a given design are also lacking. We and others are adapting 3D printing technologies to generate complex and bioinspired vascular geometries that can support the transport needs of large 3D tissues. We applied computational tools and linked them to experimental analyses of convective and diffusive transport provided by three-dimensional vascular networks. Human vasculature is multiscale with fractal complexity; to begin to approach this complexity we designed and studied mimics of specific aspects of vascular anatomy such as branching blood vessel networks and intravascular bicuspid valves. Our perfusable vessels supported arterial pressures, so we further investigated the feasibility of surgically connecting our constructs directly to host vasculature in small and large animal studies. The objective of this work is to close the loop between computational and experimental models involving blood flow and mass transport in vascular networks, allowing scientists to more effectively design and fabricate vascularized tissues. This work provides a quantitative roadmap for the design of vascular networks and the evaluation of their function within 3D tissue constructs.
dc.format.mimetypeapplication/pdf
dc.identifier.citationPaulsen, Samantha Jean. "Computational and experimental models of vascular transport in engineered tissues." (2018) Diss., Rice University. <a href="https://hdl.handle.net/1911/105738">https://hdl.handle.net/1911/105738</a>.
dc.identifier.urihttps://hdl.handle.net/1911/105738
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectTissue engineering
dc.subject3D printing
dc.subjectcomputational fluid dynamics
dc.subject
dc.titleComputational and experimental models of vascular transport in engineered tissues
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBioengineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.majorTissue Engineering
thesis.degree.nameDoctor of Philosophy
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