Protein wrapping and protein hydration

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dc.contributor.advisorFernandez, Ariel
dc.creatorChen, Jianping
dc.date.accessioned2018-12-03T18:32:05Z
dc.date.available2018-12-03T18:32:05Z
dc.date.issued2008
dc.description.abstractHydrogen bond plays an important role in stability, dynamics and function of protein. Most of backbone hydrogen bonds are well wrapped by nonpolar groups of side chains. However, there are a small portion of hydrogen bonds vulnerable to water attack. Those under-wrapped hydrogen bonds, termed as "dehydron", are sensitive to the change in the local electrostatic environment. Dehydrons constitute a hot spot for protein interactions. They have been identified as structural marker for protein association, proteamic connectivity and protein-ligand binding. The effects of dehydrons on protein hydration shell are assessed by studying the mobility of hydration water. Calculation of water residence times of all residues reveals that dehydrons enhance the water mobility and promote the most intense loosening of hydration shell. Targeting loose hydration shells induced by dehydrons provides a powerful strategy in rational drug design.
dc.format.extent60 pp
dc.identifier.callnoTHESIS PHYS. 2008 CHEN
dc.identifier.citationChen, Jianping. "Protein wrapping and protein hydration." (2008) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/103640">https://hdl.handle.net/1911/103640</a>.
dc.identifier.digital304532925
dc.identifier.urihttps://hdl.handle.net/1911/103640
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiomedical research
dc.subjectBiophysics
dc.subjectApplied sciences
dc.subjectBiological sciences
dc.titleProtein wrapping and protein hydration
dc.typeThesis
dc.type.materialText
thesis.degree.departmentPhysics
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
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