Two-dimensional (2D) materials have shown promising gas sensing capabilities due to their high surface-to-volume ratio and excellent electronic characteristics. However, the weak signals generated by 2D sensors are typically measured using ultra-precise but bulky electrical characterization equipment. Despite their potential, 2D material-based gas sensors have not yet been widely integrated into Internet of Things (IoT) systems for real-time, wireless, and continuous gas monitoring in both urban and industrial settings. This work presents an integrated 2D material-based gas sensing platform that amplifies low-intensity sensing signals on-site and employs Bluetooth 5 technology for long-range, real-time data transmission. It facilitates high-quality data collection from remote 2D gas sensors, addressing modern needs for life safety, smart living, efficient production, and environmental preservation. The thesis introduces 2D material-based gas sensors, details the development of the wireless transmission system, and describes the fabrication processes for 2D sensors and antennas. The creation of this platform lays the foundation for artificial intelligence-assisted, data-driven gas sensing with 2D materials, offering a promising approach to overcoming the selectivity limitations of chemiresistive-type 2D gas sensors, which yields richer insights into sensing behavior and ultimately deepens the understanding of the dynamics of modern human living conditions.