A mathematical model of the mammalian ventricular cell: Mechanistic explanations of long Q-T syndrome

Simple item page
dc.contributor.advisorClark, John W., Jr.en_US
dc.creatorDaniel, Kimberly Nicholeen_US
dc.date.accessioned2009-06-04T08:06:33Zen_US
dc.date.available2009-06-04T08:06:33Zen_US
dc.date.issued2002en_US
dc.description.abstractWe have developed a mathematical model of a rabbit ventricular cell based on available whole cell voltage clamp data. The model consists of three components: a Hodgkin-Huxley type membrane model describing the electrical activity of the cell membrane; and intracellular fluid compartment model; and a small extracellular cleft space. Material balances for Na+, K +, and Ca2+ provide the describing equations for the intra and extracellular spaces. A model for the sarcoplasmic reticulum is also provided in the intracellular fluid compartment model. Whole cell voltage clamp data from the rabbit ventricular myocyte was utilized to characterize the kinetics of the ionic membrane currents. Parameters associated with the ionic currents can be adjusted to yield good fits to measured action potential and Ca2+ transient waveforms recorded in our laboratory. Moreover, the model can be employed to qualitatively predict the ionic mechanisms underlying repolarization.en_US
dc.format.extent85 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS E.E. 2002 DANIELen_US
dc.identifier.citationDaniel, Kimberly Nichole. "A mathematical model of the mammalian ventricular cell: Mechanistic explanations of long Q-T syndrome." (2002) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17498">https://hdl.handle.net/1911/17498</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/17498en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCell biologyen_US
dc.subjectElectronicsen_US
dc.subjectElectrical engineeringen_US
dc.titleA mathematical model of the mammalian ventricular cell: Mechanistic explanations of long Q-T syndromeen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1408657.PDF
Size:
2.49 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Theses and Dissertations