Chronic large-scale recording and stimulation enabled by ultra-flexible high-density neural probes and an implantation robot

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dc.contributor.advisorXie, Chongen_US
dc.creatorWang, Weinanen_US
dc.date.accessioned2024-01-22T21:19:39Zen_US
dc.date.available2024-01-22T21:19:39Zen_US
dc.date.created2023-12en_US
dc.date.issued2023-10-17en_US
dc.date.submittedDecember 2023en_US
dc.date.updated2024-01-22T21:19:39Zen_US
dc.descriptionEMBARGO NOTE: This item is embargoed until 2025-12-01en_US
dc.description.abstractUltraflexible nanoelectronic neural probes have shown their capabilities in stable long-term recording at a wide range of spatial-temporal scales and a high resolution from animal brains, thanks to their miniaturized electrode configurations and close-to-tissue mechanical compliance that contribute to a glial scar-free interface. These features also enable them to be integrated with imaging systems for neuron ensemble and vasculature study. However, current neural recording devices cannot record and process data from a large across-brain-region scale at a cellular level, while ensuring the free movement of an animal. Here, we present electron-beam lithography (EBL) fabricated high-density flexible probes with up to 1024 channels. They record spikes from free-moving rats with little amplitude degradation over up to 3 months. The ultraflexible polymer probes can be integrated with a lightweight, densely packed application-specific integrated circuit (ASIC) that enables simultaneous multi-thousand channel recording. We further propose a semi-automated implantation robot that has 32 individually and simultaneously addressable arms that integrate with probes, capable of inserting the shanks into a rodent’s brain at any geometric configuration at a wide range of speed per user’s need. The robot provides a reliable solution for parallel and independent insertion, which is useful for reducing implantation time and the adverse biological response. To our knowledge, it is so far the largest configurable parallel implantation system. We believe the high-density probes in combination with the high degree-of-freedom manipulation of the implantation will be an enabling technology in neuroscience studies in animal models, as well as in clinical applications.en_US
dc.embargo.lift2025-12-01en_US
dc.embargo.terms2025-12-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationWang, Weinan. "Chronic large-scale recording and stimulation enabled by ultra-flexible high-density neural probes and an implantation robot." (2023) Master's thesis, Rice University. https://hdl.handle.net/1911/115337en_US
dc.identifier.urihttps://hdl.handle.net/1911/115337en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectUltraflexibleen_US
dc.subjectnanoelectronicen_US
dc.subjectneural probesen_US
dc.subjectmulti electrode arraysen_US
dc.subjectchronic recordingen_US
dc.subjectneuron stimulationen_US
dc.subjecthigh spatio-temporal resolutionen_US
dc.subjecthigh channel densityen_US
dc.subjectneural spikes recording and trackingen_US
dc.subjectimplantation roboten_US
dc.subjectsimultaneous implantationen_US
dc.subjectconfigurable implantation sitesen_US
dc.titleChronic large-scale recording and stimulation enabled by ultra-flexible high-density neural probes and an implantation roboten_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentApplied Physicsen_US
thesis.degree.disciplineApplied Physics/Electrical Engen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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