Dense and persistent odor representations in the olfactory bulb of awake mice

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dc.contributor.advisorPatel, Ankit Ben_US
dc.creatorPirhayatifard, Delaramen_US
dc.date.accessioned2024-01-22T21:29:27Zen_US
dc.date.available2024-01-22T21:29:27Zen_US
dc.date.created2023-12en_US
dc.date.issued2023-10-16en_US
dc.date.submittedDecember 2023en_US
dc.date.updated2024-01-22T21:29:27Zen_US
dc.description.abstractIn this study, we explore odor-evoked activity representation in the olfactory bulb (OB) and how odor responses enable odor discrimination. Contrary to some of the previously cited theories that suggest a sparse representation and largely rely on recordings from anesthetized animals, we hypothesize a more dense representation during and after odor presentation. A key question is how odors are reliably encoded in complex OB activity patterns, and how these patterns contribute to early odor processing. To address this problem, we recorded population level odor responses from the mouse OB with meso-scale two photon calcium imaging and applied machine learning and statistical analysis to suggest a model in which sparse coding is largely sufficient for olfaction, but redundant information may make odor coding more robust across different internal and environmental variables.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationPirhayatifard, Delaram. "Dense and persistent odor representations in the olfactory bulb of awake mice." (2023) Master's thesis, Rice University. https://hdl.handle.net/1911/115341en_US
dc.identifier.urihttps://hdl.handle.net/1911/115341en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectcalcium imagingen_US
dc.subjectolfactory bulben_US
dc.subjectmachine learningen_US
dc.subjectodor discriminationen_US
dc.titleDense and persistent odor representations in the olfactory bulb of awake miceen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical and Computer Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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