Label-free Imaging of Thyroid and Parathyroid Glands Using Coherent Anti-Stokes Raman Scattering (CARS) Microscopy

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dc.contributor.advisorKelly, Kevinen_US
dc.contributor.committeeMemberWong, Stephenen_US
dc.contributor.committeeMemberThomann, Isabellen_US
dc.contributor.committeeMemberKono, Junichiroen_US
dc.creatorWeng, Shengen_US
dc.date.accessioned2016-02-05T22:05:58Zen_US
dc.date.available2016-02-05T22:05:58Zen_US
dc.date.created2015-05en_US
dc.date.issued2015-04-28en_US
dc.date.submittedMay 2015en_US
dc.date.updated2016-02-05T22:05:58Zen_US
dc.description.abstractThyroid and parathyroid glands play a vital role in regulating the body's metabolism and calcium levels. Surgical removal of the glands is the main treatment for both thyroid cancer and parathyroid adenoma. In thyroidectomy and parathyroidectomy, it's very important to differentiate thyroid, parathyroid, and the other tissues around the neck. Traditionally, physicians use ultrasound guided fine needle aspiration (FNA) to evaluate thyroid nodules, but up to 30% of FNA results are “inconclusive”. The sestamibi scan can localize parathyroid adenoma, but currently it only has 50% accuracy. Here we applied the emerging CARS technique to image both thyroid and parathyroid tissues, which has potential to be used in real-time in vivo examination of different structures. We also developed algorithms to differentiate different cellular structures based on CARS images. When incorporated with a fiber optic endoscope in the future, CARS imaging technique can help surgeons identify cancerous thyroid tissue intraoperatively, preserve good parathyroid glands during thyroidectomy and find parathyroid adenoma during parathyroidectomy.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationWeng, Sheng. "Label-free Imaging of Thyroid and Parathyroid Glands Using Coherent Anti-Stokes Raman Scattering (CARS) Microscopy." (2015) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/88429">https://hdl.handle.net/1911/88429</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/88429en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCARS imagingen_US
dc.subjectThyroiden_US
dc.subjectParathyroiden_US
dc.subjectNuclei segmentationen_US
dc.titleLabel-free Imaging of Thyroid and Parathyroid Glands Using Coherent Anti-Stokes Raman Scattering (CARS) Microscopyen_US
dc.typeThesisen_US
dc.type.genrecomputer languages and codeen_US
dc.type.materialTexten_US
thesis.degree.departmentApplied Physicsen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.majorApplied Physics/Electrical Engen_US
thesis.degree.nameMaster of Scienceen_US
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