Encapsulated Cell Systems for Treating Inflammatory Diseases

Simple item page
dc.contributor.advisorVeiseh, Omid
dc.contributor.committeeMemberGhanta, Ravi K
dc.creatorAghlara-Fotovat, Samira
dc.date.accessioned2024-05-22T18:13:46Z
dc.date.created2024-05
dc.date.issued2024-04-19
dc.date.submittedMay 2024
dc.date.updated2024-05-22T18:13:46Z
dc.descriptionEMBARGO NOTE: This item is embargoed until 2026-05-01
dc.description.abstractIn response to pathogens and trauma, host immune cells interact bi-directionally with their local environment to receive and deposit molecular signals, which orchestrate cellular activation, proliferation, differentiation, and function to maintain healthy tissue homeostasis. While our immune system functions as a vigilant safeguard against environmental threats, instances of immune dysregulation may occur, leading to uncontrolled responses. In these conditions, it is essential to restore balance to the body through modulation of the immune system and the ECM. Cell-based therapeutics have significant potential in locally monitoring and treating inflammatory diseases, however, their widespread use is hindered by recognition and elimination by the host. Thus, novel technologies that can improve the viability and function of cell-based therapies have significant potential in improving translation. Here, we aim to utilize biomaterial encapsulation as a tool for improving the delivery of cell-based therapeutics for local immunomodulation in various inflammatory diseases including myocardial infarct, acute respiratory distress syndrome, neural inflammation, inflammatory bowel disease.
dc.embargo.lift2026-05-01
dc.embargo.terms2026-05-01
dc.format.mimetypeapplication/pdf
dc.identifier.citationAghlara-Fotovat, Samira. Encapsulated Cell Systems for Treating Inflammatory Diseases. (2024). PhD diss., Rice University. https://hdl.handle.net/1911/116256
dc.identifier.urihttps://hdl.handle.net/1911/116256
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectInflammation
dc.subjectInterleukin 10
dc.subjectInterleukin 1 receptor antagonist
dc.subjectacute respiratory distress
dc.subjectmyocardial infarct
dc.subjectneuro inflammation
dc.subjectimmunomodulation
dc.subjectcytokine
dc.subjecthydrogel
dc.subjectcell encapsulation
dc.titleEncapsulated Cell Systems for Treating Inflammatory Diseases
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBioengineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
Files
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.85 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
2.99 KB
Format:
Plain Text
Description:
Download
Collections
Rice University Electronic Theses and Dissertations