Encapsulated Cell Systems for Treating Inflammatory Diseases

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dc.contributor.advisorVeiseh, Omiden_US
dc.contributor.committeeMemberGhanta, Ravi Ken_US
dc.creatorAghlara-Fotovat, Samiraen_US
dc.date.accessioned2024-05-22T18:13:46Zen_US
dc.date.created2024-05en_US
dc.date.issued2024-04-19en_US
dc.date.submittedMay 2024en_US
dc.date.updated2024-05-22T18:13:46Zen_US
dc.descriptionEMBARGO NOTE: This item is embargoed until 2026-05-01en_US
dc.description.abstractIn response to pathogens and trauma, host immune cells interact bi-directionally with their local environment to receive and deposit molecular signals, which orchestrate cellular activation, proliferation, differentiation, and function to maintain healthy tissue homeostasis. While our immune system functions as a vigilant safeguard against environmental threats, instances of immune dysregulation may occur, leading to uncontrolled responses. In these conditions, it is essential to restore balance to the body through modulation of the immune system and the ECM. Cell-based therapeutics have significant potential in locally monitoring and treating inflammatory diseases, however, their widespread use is hindered by recognition and elimination by the host. Thus, novel technologies that can improve the viability and function of cell-based therapies have significant potential in improving translation. Here, we aim to utilize biomaterial encapsulation as a tool for improving the delivery of cell-based therapeutics for local immunomodulation in various inflammatory diseases including myocardial infarct, acute respiratory distress syndrome, neural inflammation, inflammatory bowel disease.en_US
dc.embargo.lift2026-05-01en_US
dc.embargo.terms2026-05-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationAghlara-Fotovat, Samira. Encapsulated Cell Systems for Treating Inflammatory Diseases. (2024). PhD diss., Rice University. https://hdl.handle.net/1911/116256en_US
dc.identifier.urihttps://hdl.handle.net/1911/116256en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectInflammationen_US
dc.subjectInterleukin 10en_US
dc.subjectInterleukin 1 receptor antagonisten_US
dc.subjectacute respiratory distressen_US
dc.subjectmyocardial infarcten_US
dc.subjectneuro inflammationen_US
dc.subjectimmunomodulationen_US
dc.subjectcytokineen_US
dc.subjecthydrogelen_US
dc.subjectcell encapsulationen_US
dc.titleEncapsulated Cell Systems for Treating Inflammatory Diseasesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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