The effect of an oral or intravenous nucleotide-free diet on selected enzyme activities in purine metabolism in rats

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dc.contributor.advisorRudolph, Frederick B.
dc.contributor.committeeMemberBerget, Susan M.
dc.contributor.committeeMemberSchroepfer, George J.
dc.contributor.committeeMemberBennett, George
dc.contributor.committeeMemberStorck, Roger L.
dc.creatorSnyder, Sandra Lynn
dc.date.accessioned2018-12-18T21:22:31Z
dc.date.available2018-12-18T21:22:31Z
dc.date.issued1982
dc.description.abstractInterrelationships between purine metabolism and immunity, cancer, and the diet have been considered. In studying trends of metabolic changes which occur in response to changes in the purine content of the diet, it has been hypothesized that when purines are lacking from the diet, there is a general shift from a catabolic to an anabolic state. In the present investigation, the activities of selected enzymes on purine metabolism in rats were studied with respect to an oral or intravenous nucleotide-free diet compared to the activities in rats fed normal chow. The intravenous nucleotide-free diet caused a decrease in purine nucleoside phosphorylase activity, an increase in adenine phosphoribosyl transferase, and no change in the activity of hypoxanthine-guanine phosphoribosyl transferase, with respect to a normal control diet. The orally fed nucleotide-free diet caused a decrease in the activity of purine nucleoside phosphorylase and xanthine oxidase and increase in pancreatic ribonucléase and no change in adenine phosphoribosyl transferase or hyphoxanthine-guanine phosphoribosyl transferase, with respect to a normal control diet. These observations support the predicted shift from catabolism to anabolism. They also augment the growing awareness of the interrelationships between diet and cancer as well as diet and the immune response.
dc.format.digitalOriginreformatted digital
dc.format.extent69 pp
dc.identifier.callnoThesis Biochem. 1982 Snyder
dc.identifier.citationSnyder, Sandra Lynn. "The effect of an oral or intravenous nucleotide-free diet on selected enzyme activities in purine metabolism in rats." (1982) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/104405">https://hdl.handle.net/1911/104405</a>.
dc.identifier.digitalRICE2040
dc.identifier.urihttps://hdl.handle.net/1911/104405
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.titleThe effect of an oral or intravenous nucleotide-free diet on selected enzyme activities in purine metabolism in rats
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBiochemistry and Cell Biology
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts
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