Small Gold Nanostruct​ures in Cancer Theranosti​cs

Thibodeaux, Christyn A.

Small Gold Nanostructures in Cancer Theranostics

dc.contributor.advisor	Halas, Naomi J.	en_US
dc.contributor.committeeMember	Nordlander, Peter J.	en_US
dc.contributor.committeeMember	Link, Stephan	en_US
dc.creator	Thibodeaux, Christyn A.	en_US
dc.date.accessioned	2014-10-14T15:55:00Z	en_US
dc.date.available	2014-10-14T15:55:00Z	en_US
dc.date.created	2014-05	en_US
dc.date.issued	2014-04-25	en_US
dc.date.submitted	May 2014	en_US
dc.date.updated	2014-10-14T15:55:00Z	en_US
dc.description.abstract	The development of small (40-150nm) nanoparticles is of significant interest in biomedicine for effective detection and delivery of therapeutic molecules to diseased cells. The optical exploration of hollow gold nanoshells with sacrificial Co cores reveals the spectral FWHM increases due to the presence of Co while only minimally altering the spectral mean wavelength position. Other plasmon resonant nanostructures including nanoshells and nanomatryoshkas are valuable delivery and imaging vectors for oligonucleotide based therapies. In this study, light-triggered release of siRNA hybridized to a polypeptide functionalized NS is employed for gene silencing therapy of a specific pathogenic gene transcript with the intent to downregulate proteins. Similarly, fluorescently labeled NM are conjugated with an ESTA-1 aptamer via for bioimaging of highly specific inflammation targeting at metastasis sites. Each having advantageous platforms of ideal size, therapeutic gene optimization and heightened metastasis targeting, these three nanostructures prove viable functionality in cancer theranostics.	en_US
dc.format.mimetype	application/pdf	en_US
dc.identifier.citation	Thibodeaux, Christyn A.. "Small Gold Nanostructures in Cancer Theranostics." (2014) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/77565">https://hdl.handle.net/1911/77565</a>.	en_US
dc.identifier.uri	https://hdl.handle.net/1911/77565	en_US
dc.language.iso	eng	en_US
dc.rights	Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.	en_US
dc.subject	Nanoparticles	en_US
dc.subject	Cobalt	en_US
dc.subject	Damping	en_US
dc.subject	Light triggered release	en_US
dc.subject	Plasmon tunability	en_US
dc.subject	Cancer theranostics	en_US
dc.title	Small Gold Nanostructures in Cancer Theranostics	en_US
dc.type	Thesis	en_US
dc.type.material	Text	en_US
thesis.degree.department	Electrical and Computer Engineering	en_US
thesis.degree.discipline	Engineering	en_US
thesis.degree.grantor	Rice University	en_US
thesis.degree.level	Masters	en_US
thesis.degree.name	Master of Science	en_US