To fully exploit emerging processor architectures, programs will need to employ threaded parallelism within a node and message passing across nodes. Today, MPI+OpenMP is the preferred programming model for this task. However, tuning MPI+OpenMP programs for clusters is difficult. Performance tools can help users identify bottlenecks and uncover opportunities for improvement. Applications to analyze seismic data employ scalable parallel systems to produce timely results. This thesis describes our experiences of applying performance tools to gain insight into an MPI+OpenMP code that performs Reverse Time Migration (RTM) to analyze seismic data and also assess the capabilities of available tools for analyzing the performance of a sophisticated application that employ both message-passing and threaded parallelism. The tools provided us with insights into the effectiveness of the domain decomposition strategy, the use of threaded parallelism, and functional unit utilization in individual cores. By applying insights obtained from Rice University's HPCToolkit and hardware performance counters, we were able to improve the performance of the RTM code by roughly 30 percent.