A model of sarcolemmal calcium(2+) currents and cytosolic calcium(2+) transients in a rat ventricular cell

Simple item page
dc.contributor.advisorClark, John W., Jr.
dc.creatorSun, Liang
dc.date.accessioned2009-06-04T08:19:25Z
dc.date.available2009-06-04T08:19:25Z
dc.date.issued2000
dc.description.abstractWe have developed a mathematical model of the L-type Ca2+ current and cytosolic Ca2+ transient, which is based on data from whole-cell voltage clamp experiments on rat ventricular myocytes. Modified Goldman-Hodgkin-Katz (GHK) equations are provided to account for the different ion selectivity of the DHP-sensitive Ca2+ current channel. The decay of whole cell currents obtained by maintained depolarization is characterized by means of voltage and Ca2+-dependent inactivation embedded in a 5-state dynamic DHP channel model. To characterize a reduced amount of steady-state inactivation of DHP channel in the presence of [Ca 2+]o, a mechanism is used in the model whereby Ca 2+ also inhibits the voltage-dependent inactivation pathway. The 5-state DHP model is also used to simulate single-channel activity. Cytosolic Ca 2+ transients are studied as well. They derive mainly from secondary Calcium-Induced-Calcium-Release (CICR) from the Sarcoplasmic Reticulum (SR). We have developed a 4-state RyR-sensitive Ca2+ model that describes the kinetics of the release channel. This model provides close fitting of cytosolic Ca2+-transient data and mimics the high gain, graded Ca2+ release behavior of the channel. Overall, the model provides a quantitative description of the Ca2+ subsystem in the mammalian heart.
dc.format.extent85 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS E.E. 2000 SUN
dc.identifier.citationSun, Liang. "A model of sarcolemmal calcium(2+) currents and cytosolic calcium(2+) transients in a rat ventricular cell." (2000) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17383">https://hdl.handle.net/1911/17383</a>.
dc.identifier.urihttps://hdl.handle.net/1911/17383
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiomedical engineering
dc.subjectBiophysics
dc.titleA model of sarcolemmal calcium(2+) currents and cytosolic calcium(2+) transients in a rat ventricular cell
dc.typeThesis
dc.type.materialText
thesis.degree.departmentElectrical Engineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1399310.PDF
Size:
2.78 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Electronic Theses and Dissertations
ECE Theses and Dissertations