Nanofiber Formation by Collagen Mimetic Peptides: Elucidation of Supramolecular Principles and Application of Retrosynthetic Analysis

Simple item page
dc.contributor.advisorHartgerink, Jeffrey D.en_US
dc.contributor.committeeMemberMatsuda, Seiichi P. T.en_US
dc.contributor.committeeMemberTao, Yizhi J.en_US
dc.creatorSarkar, Biplaben_US
dc.date.accessioned2016-01-26T21:30:34Zen_US
dc.date.available2016-01-26T21:30:34Zen_US
dc.date.created2015-05en_US
dc.date.issued2015-05-14en_US
dc.date.submittedMay 2015en_US
dc.date.updated2016-01-26T21:30:34Zen_US
dc.description.abstractSynthetic mimics of the fibrillar protein collagen were designed by engineering specific supramolecular interactions in the triple helical building blocks. My doctoral research indicates that tri-domain collagen mimetic peptides, with positive, neutral, and negative domains, may form nanofibrous assembly through a staggered triple-helical intermediate stabilized by inter-strand charge pairs. Based on our understanding of the fibrillation pathway, I have devised a supramolecular retrosynthetic strategy to prepare collagen mimetic nanofibers. By designing an infinite triple helix with optimal number of inter-strand charge pairs, and then identifying the requisite building blocks, I was able to prepare a two-component collagen mimetic fiber with a high melting temperature. Peptide-based collagen mimetic nanofibers have great potential for future medical applications.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationSarkar, Biplab. "Nanofiber Formation by Collagen Mimetic Peptides: Elucidation of Supramolecular Principles and Application of Retrosynthetic Analysis." (2015) Diss., Rice University. <a href="https://hdl.handle.net/1911/88141">https://hdl.handle.net/1911/88141</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/88141en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCollagenen_US
dc.subjectCollagen Mimetic Peptideen_US
dc.subjectNanofiberen_US
dc.subjectSupramolecular Retrosynthesisen_US
dc.subjectFiber Diffractionen_US
dc.subjectMulti-Component Fiberen_US
dc.titleNanofiber Formation by Collagen Mimetic Peptides: Elucidation of Supramolecular Principles and Application of Retrosynthetic Analysisen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
SARKAR-DOCUMENT-2015.pdf
Size:
28.26 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.84 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
2.61 KB
Format:
Plain Text
Description:
Download
Collections
Rice University Theses and Dissertations