A Sequence-Based, Population Genetic Model of Regulatory Pathway Evolution

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dc.contributor.advisorNakhleh, Luay K.en_US
dc.creatorRuths, Troyen_US
dc.date.accessioned2013-03-08T00:38:20Zen_US
dc.date.available2013-03-08T00:38:20Zen_US
dc.date.issued2011en_US
dc.description.abstractComplex phenotypes with genetic cause are understood through many processes, including regulatory pathways, but our evolutionary understanding of these critical structures is undermined by poor models which fail to preserve the underlying sequence structure and to incorporate population genetics. In response, this thesis builds a pathway model of evolution from its underlying sequence structure and validates it against a pertinent problem in genome evolution which uniquely leverage the developed model. Specifically, my model preserves sequence characteristics through a novel data structure and pathway-level mutation and recombination rates which are functions of sequence properties. The utility of the model is validated with a study quantifying the advantages and disadvantages of expansive non-coding DNA regions on the establishment of optimal pathways. Because the model presented in this thesis rectifies many fundamental problems in previous models, it may serve as a critical tool for future work in pathway evolution.en_US
dc.format.extent81 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS COMP.SCI. 2011 RUTHSen_US
dc.identifier.citationRuths, Troy. "A Sequence-Based, Population Genetic Model of Regulatory Pathway Evolution." (2011) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/70420">https://hdl.handle.net/1911/70420</a>.en_US
dc.identifier.digitalRuthsTen_US
dc.identifier.urihttps://hdl.handle.net/1911/70420en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectApplied sciencesen_US
dc.subjectBiological sciencesen_US
dc.subjectEvolution & developmenten_US
dc.subjectBioinformaticsen_US
dc.subjectComputer scienceen_US
dc.titleA Sequence-Based, Population Genetic Model of Regulatory Pathway Evolutionen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentComputer Scienceen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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