A mathematical reconstruction of the frog atrial action potential based on voltage clamp data

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dc.contributor.advisorClark, John W.en_US
dc.contributor.committeeMemberGlantz, Raymon M.en_US
dc.contributor.committeeMemberJohnson, Don H.en_US
dc.creatorRobinson, Keithen_US
dc.date.accessioned2018-12-18T21:19:22Zen_US
dc.date.available2018-12-18T21:19:22Zen_US
dc.date.issued1983en_US
dc.descriptionNo page 82en_US
dc.description.abstractRecent advances in cardiac electrophysiology have allowed for the preparation of viable single frog atrial cells. These cells have properties which make them ideal for voltage clamp studies. The ionic currents observed under voltage clamp conditons from single frog atrial cells are analyzed with the use of automatic methods programmed on a computer. From the analyzed data, mathematical models are formed which describe the time and voltage dependence of the various ionic currents observed under voltage clamp conditions. These models are then combined, and a membrane action potential is reconstructed based on the analyzed ionic current data. This membrane action potential is then used as input to a nonlinear least-squares fitting routine in an attempt to accurately fit the model to experimental action potential data.en_US
dc.format.digitalOriginreformatted digitalen_US
dc.format.extent250 ppen_US
dc.identifier.callnoTHESIS E.E. 1983 ROBINSONen_US
dc.identifier.citationRobinson, Keith. "A mathematical reconstruction of the frog atrial action potential based on voltage clamp data." (1983) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/104236">https://hdl.handle.net/1911/104236</a>.en_US
dc.identifier.digitalRICE1865en_US
dc.identifier.urihttps://hdl.handle.net/1911/104236en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.titleA mathematical reconstruction of the frog atrial action potential based on voltage clamp dataen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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