Synthesis and Applications of Dirhodium Metallopeptides

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dc.contributor.advisorBall, Zachary T.en_US
dc.contributor.committeeMemberParry, Ronald J.en_US
dc.contributor.committeeMemberSilberg, Jonathan J.en_US
dc.creatorZaykov, Alexanderen_US
dc.date.accessioned2012-09-05T23:54:41Zen_US
dc.date.accessioned2012-09-05T23:54:57Zen_US
dc.date.available2012-09-05T23:54:41Zen_US
dc.date.available2012-09-05T23:54:57Zen_US
dc.date.created2012-05en_US
dc.date.issued2012-09-05en_US
dc.date.submittedMay 2012en_US
dc.date.updated2012-09-05T23:54:57Zen_US
dc.description.abstractThe work describes the development of a new class of synthetic metallopeptides that features a dirhodium metal center. Combination of peptide and dirhodium properties leads to unique effects on peptide structure, peptide-protein interactions, and metal catalytic activity aimed at small molecule as well as protein substrates. Dirhodium is directly bound to carboxylate side chains of aspartate or glutamate yielding kinetically inert coordination complexes. This improves stability, allows purification and provides enhanced biocompatibility. Bridging of two side chains in the same sequence enables control of the peptide secondary structure. Dirhodium metallopeptides are applied to regulate coiled coil dimerization, stabilize and induce helical secondary structure, catalyze enantioselective organometallic transformation, and serve as ligands for proteins. These results lead to the development of hybrid organic-inorganic therapeutic agents, biological probes for study of protein-protein interactions, and enantioselective metallopeptide catalysis.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationZaykov, Alexander. "Synthesis and Applications of Dirhodium Metallopeptides." (2012) Diss., Rice University. <a href="https://hdl.handle.net/1911/64613">https://hdl.handle.net/1911/64613</a>.en_US
dc.identifier.slug123456789/ETD-2012-05-56en_US
dc.identifier.urihttps://hdl.handle.net/1911/64613en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectMetallopeptidesen_US
dc.subjectPeptideen_US
dc.subjectDirhodiumen_US
dc.subjectRhodiumen_US
dc.subjectHelixen_US
dc.subjectSecondary structureen_US
dc.subjectCatalysisen_US
dc.subjectInhibitionen_US
dc.subjectSite-specific labellingen_US
dc.subjectOrganic chemistryen_US
dc.titleSynthesis and Applications of Dirhodium Metallopeptidesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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