Synthesis and Applications of Dirhodium Metallopeptides

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dc.contributor.advisorBall, Zachary T.
dc.contributor.committeeMemberParry, Ronald J.
dc.contributor.committeeMemberSilberg, Jonathan J.
dc.creatorZaykov, Alexander
dc.date.accessioned2012-09-05T23:54:41Z
dc.date.accessioned2012-09-05T23:54:57Z
dc.date.available2012-09-05T23:54:41Z
dc.date.available2012-09-05T23:54:57Z
dc.date.created2012-05
dc.date.issued2012-09-05
dc.date.submittedMay 2012
dc.date.updated2012-09-05T23:54:57Z
dc.description.abstractThe work describes the development of a new class of synthetic metallopeptides that features a dirhodium metal center. Combination of peptide and dirhodium properties leads to unique effects on peptide structure, peptide-protein interactions, and metal catalytic activity aimed at small molecule as well as protein substrates. Dirhodium is directly bound to carboxylate side chains of aspartate or glutamate yielding kinetically inert coordination complexes. This improves stability, allows purification and provides enhanced biocompatibility. Bridging of two side chains in the same sequence enables control of the peptide secondary structure. Dirhodium metallopeptides are applied to regulate coiled coil dimerization, stabilize and induce helical secondary structure, catalyze enantioselective organometallic transformation, and serve as ligands for proteins. These results lead to the development of hybrid organic-inorganic therapeutic agents, biological probes for study of protein-protein interactions, and enantioselective metallopeptide catalysis.
dc.format.mimetypeapplication/pdf
dc.identifier.citationZaykov, Alexander. "Synthesis and Applications of Dirhodium Metallopeptides." (2012) Diss., Rice University. <a href="https://hdl.handle.net/1911/64613">https://hdl.handle.net/1911/64613</a>.
dc.identifier.slug123456789/ETD-2012-05-56
dc.identifier.urihttps://hdl.handle.net/1911/64613
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectMetallopeptides
dc.subjectPeptide
dc.subjectDirhodium
dc.subjectRhodium
dc.subjectHelix
dc.subjectSecondary structure
dc.subjectCatalysis
dc.subjectInhibition
dc.subjectSite-specific labelling
dc.subjectOrganic chemistry
dc.titleSynthesis and Applications of Dirhodium Metallopeptides
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemistry
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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