Carbon Nanotube Fiber Microelectrode Arrays for Neural Recording and Stimulation Applications

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dc.contributor.advisorPasquali, Matteoen_US
dc.creatorPamulapati, Sushma Srien_US
dc.date.accessioned2021-08-16T19:51:41Zen_US
dc.date.available2023-08-01T05:01:12Zen_US
dc.date.created2021-08en_US
dc.date.issued2021-08-16en_US
dc.date.submittedAugust 2021en_US
dc.date.updated2021-08-16T19:51:41Zen_US
dc.description.abstractImplantable neural interfaces that can simultaneously record and perturb the neuronal circuitry with neuron scale precision have profound implications in neuroscience and medicine. They hold great potential for the diagnosis and treatment of several neurological disorders such as Parkinson's disease and epilepsy. In addition, they play a crucial role in the development of neuroprosthetics and brain-computer interface (BCI) technologies that can restore functionality in patients with nervous system impairments. Despite the promise of such neuron-scale interfaces, most of the neural electrode technologies developed to date are incapable of providing simultaneous multi-channel neural recording in conjunction with micro stimulation desired for the above stated applications [59]. For instance, metal electrodes suffer limited performance in providing stable neuronal scale recording and micro stimulation because of their poor electrochemical and mechanical properties. Carbon nanotube (CNT) fiber is a novel material with a unique combination of extraordinary electrical, thermal, and mechanical properties like CNTs, their microscopic counterparts [6]. Recent studies show CNT fibers (CNTfs) as the ideal candidate material for the development of safe, effective, stable, and multifunctional neural microelectrodes without the need for any additional surface modification [78, 143, 144, 165]. This dissertation focused on developing a scaled-up high density, CNTf microelectrode array for simultaneous recording and micro-stimulation. The thesis has two portions. In the first, we present a parylene-C insulation scheme for CNTf electrodes, the first step in CNTf -based electrode development. The integrity of parylene-C coated CNTf electrodes was evaluated using modified leakage current, electron microscopy, bending stiffness, and in vitro electrochemical analysis under normal and H2O2 aging conditions at different temperatures. We demonstrated that the parylene-C alone scheme offers high conformal, flexible, minimal leakage current, and stable long-term insulation performance and is a better insulation strategy for CNTf electrodes. In the second part of this thesis, we developed and optimized micro fabrication and assembly techniques to successfully fabricate multi-channel parylene-C coated CNTf microelectrode arrays (n=8/16/32). The novel arrays demonstrate one of the lowest electrode channel impedance, high charge storage injection capacity to the metal and state-of-the-art neural electrode materials in vitro. In the final portion, we validated the implantation strategy and recording function of the developed arrays to metal electrodes using acute in vivo studies in rat models. The combination of the low impedance, better charge transfer properties, and the initial in vivo performance of the developed CNTf electrode arrays suggest they are a promising technology for neural recording and stimulation applications.en_US
dc.embargo.terms2023-08-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationPamulapati, Sushma Sri. "Carbon Nanotube Fiber Microelectrode Arrays for Neural Recording and Stimulation Applications." (2021) Diss., Rice University. <a href="https://hdl.handle.net/1911/111219">https://hdl.handle.net/1911/111219</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/111219en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCarbon Nanotube Fibersen_US
dc.subjectNeural Electrodesen_US
dc.subjectNeuroengineeringen_US
dc.titleCarbon Nanotube Fiber Microelectrode Arrays for Neural Recording and Stimulation Applicationsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemical and Biomolecular Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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