Enabling Generalized Protein Therapeutics with Implantable Bioelectronics

dc.contributor.advisorRobinson, Jacoben_US
dc.creatorParker, Matthewen_US
dc.date.accessioned2024-01-22T22:12:45Zen_US
dc.date.available2024-01-22T22:12:45Zen_US
dc.date.created2023-12en_US
dc.date.issued2023-11-16en_US
dc.date.submittedDecember 2023en_US
dc.date.updated2024-01-22T22:12:45Zen_US
dc.description.abstractThere are more than 10,000 proteins that make up the human proteome and errors in these proteins can have devastating effects on the body. Of these more than 10,000 proteins, only a small fraction are able to be isolated and provided as exogenous therapeutics to replace proteins that are deficient or abnormal. In this paper, we have developed an implantable bioelectronic system that works in conjunction with genetically modified cells to provide controlled doses of any native peptide to the patient. The implantable system protects the modified cells from any host immune response, accurately doses the therapeutic protein by modulating activation of the protein production by the cells, and ensures long-term cell viability for prolonged treatment in patients. In addition, the implant provides biometric feedback to help determine the effectiveness of the treatment and allows healthcare providers to adjust dosing without need for explantation.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationParker, Matthew. "Enabling Generalized Protein Therapeutics with Implantable Bioelectronics." (2023) Master's thesis, Rice University. https://hdl.handle.net/1911/115347en_US
dc.identifier.urihttps://hdl.handle.net/1911/115347en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectImplantable electronicsen_US
dc.subjectprotein therapeuticsen_US
dc.titleEnabling Generalized Protein Therapeutics with Implantable Bioelectronicsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical and Computer Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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