Nonlinear dynamic analysis of non-ductile flat-plate buildings requires a suitable hysteretic model and an equivalent frame approach which appropriately models the lateral stiffness of the buildings. Based on the test results of non-ductile individual interior and exterior connections and two-bay slab-column subassemblies, hysteretic parameters related to stiffness degradation, strength deterioration and pinching of hysteretic loops are identified. The hysteretic model thus obtained is then incorporated into an equivalent frame analysis approach. The proposed equivalent frame approach is based on the equivalent beam concept which is calibrated to match the lateral stiffness and the moment-transfer strength of slab-column connections. Simulation of the load-drift response of the test subassemblies with the proposed analytical approach has good agreement with the measured response. Several slab-column buildings are designed as non-ductile systems and their response to typical earthquake loading is studied.